Impact of Lower Body Weight Support Treadmill on Cardiopulmonary Exercise Capacity and Trainability

Not Applicable

Completed

• Conditions: Healthy Volunteers
• Interventions: Other: AlterG Anti-gravity treadmill

• Registration Number: NCT02951494
• Lead Sponsor: University Medicine Greifswald

Brief Summary

The AlterG®-anti-gravity treadmill provides lower body weight support which enables individuals to exercise without feeling their full body weight. How this body weight support influences cardiovascular, respiratory, vascular and metabolic parameters is currently unclear. Further, whether body weight support influences the trainability in response to moderate continuous exercise is unknown. This investigation has two main goals. First, we explore the direct influence of lower body weight support on cardiometabolic parameters during maximal exercise testing. Second, we aim to compare changes in cardiorespiratory fitness in response to a structured exercise protocol using moderate intensity with and without lower body weight support.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-10-12
• Study First Submitted QC: 2016-10-28
• Study First Posted: 2016-11-01
• Study Start: 2017-01
• Status Verified: 2021-09
• Primary Completion: 2021-12-31
• Study Completion: 2021-12-31
• Last Update Submitted: 2022-05-18
• Last Update Posted: 2022-05-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• maximal oxygen consumption below age-sex specific standard

Exclusion Criteria

• acute infection within the last four weeks
• anemia (males: Hb < 8.1 mmol/L; females Hb < 7.4 mmol/L)
• previous reports of myo-, endo, or pericarditis
• previous stroke or acute myocardial infarction
• heart failure (NYHA > 1)
• aortic valve stenosis
• congenital heart disease
• cardiomyopathy
• severe left ventricular hypertrophy
• cardiac arrythmias
• hypertension
• diabetes
• BMI > 35
• cancer
• pregnancy
• aneurysm of aorta or cerebral arteries

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
AlterG Anti-gravity treadmill	AlterG Anti-gravity treadmill	cont. aerobic exercise training with lower body weight support

Primary Outcome Measures

Name	Time	Method
Maximal oxygen consumption	12 weeks	VO2peak \[ml/min\]

Secondary Outcome Measures

Name	Time	Method
Pulse wave velocity	12 weeks
Oxygen consumption at anaerobic threshold	12 weeks	VO2@AT

Trial Locations

Locations (1)

Cardiovascular examination center of the University Medicine Greifswald; 🇩🇪 Greifswald, Germany