Approaches to Differential Diagnosis and Risk Stratification in Patients Hospitalized With Suspected Acute Coronary Syndrome Without Persistent ST-segment Elevation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Non ST Segment Elevation Acute Coronary Syndrome
- Sponsor
- National Research Center for Preventive Medicine
- Enrollment
- 140
- Locations
- 1
- Primary Endpoint
- Clinical outcomes
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
To evaluate possibilities of rapid differential diagnosis and risk stratification in patients urgently admitted to the CCU with a suspected acute coronary syndrome without persistent ST-segment elevation (NSTEACS).
Detailed Description
Single centre prospective non-randomised non-comparative study of patients delivered by ambulance and admitted to the CCU with suspected NSTEACS. Aims of this study are: 1. To characterize the contingent of patients admitted to the CCU with suspected NSTEACS. 2. To evaluate possibilities of fast differential diagnosis and risk stratification in patients admitted to the CCU with suspected NSTEACS using clinical data, ECG, biomarker levels (hsTn, NT-proBNP, hsCPR, cardiac FABP) as well as HEART, ADAPT, EDACS, T-MACS, GRACE, ACTION and TIMI scores. 3. To evaluate the correlation between clinical data, ECG, biomarker levels (hsTn, NT-proBNP, hsCPR, cardiac FABP) as well as HEART, ADAPT, EDACS, T-MACS, GRACE, ACTION and TIMI scores with presence and severity of coronary atherosclerosis in patients admitted to the CCU (intensive care unit) with suspected NSTEACS.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Delivered by ambulance to the CCU with suspected diagnosis "acute coronary syndrome (ACS)".
- •Signed informed consent.
Exclusion Criteria
- •ACS with persistent ST-segment elevation.
- •Moribund; extremely severe condition on admission with a potentially unfavourable prognosis (cardiogenic shock, coma, cardiac arrest, an urgent need for mechanical ventilation).
- •Overt non-cardiac cause of clinical manifestations at the time of admission (bleeding, pulmonary embolism, aortic dissection, stroke).
Outcomes
Primary Outcomes
Clinical outcomes
Time Frame: 6 monts
Composite of death, (re) infarction, stroke or re-hospitalization
Final diagnosis
Time Frame: Up to 1 monts
Final diagnosis - the main reason for urgent hospitalization - according to hospital case history
Secondary Outcomes
- Death(6 months.)
- (re) infarction(Up to 1 monts)
- Stroke(6 months.)
- Re-hospitalization(6 months.)