Effects of Topical Gentamicin on the Prevention of Peritoneal Dialysis Related Infection Caused by Pseudomonas Aeruginosa
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Rate of Exit-site infection in mupirocin compared with gentamicin group
研究概览
简要总结
Peritoneal dialysis-related infection is a complication that leads to peritoneal dialysis catheter removal or patient death. The present study aimed to investigate peritoneal dialysis-related infection, causative pathogens resulting in topical 2% mupirocin ointments period compare with 0.1% gentamicin cream period. Rate of catheter removal, time to first peritoneal dialysis-related infection after apply gentamicin cream.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age greater than or equal to 20 years
- •End stage renal disease patients on peritoneal dialysis follow up at Phramongkutklao hospital's peritoneal dialysis clinic between January 1, 2021 to March 31, 2023
- •Start peritoneal dialysis or follow up at Phramongkutklao hospital's peritoneal dialysis clinic at least 90 days before recruited
- •Use topical mupirocin ointment for prevention of peritoneal dialysis-related infection between January 1, 2021 to December 31, 2021
- •Can be used LINE application throughout the study
排除标准
- •Allergy to gentamicin or components
- •Previous systemic antibiotics use within 90 days before recruited
- •Previous peritoneal dialysis-related infection within 28 days before recruited
- •Immunosuppressants used
- •Prospective follow up less than 2 months
- •Don't sign informed consent
研究组 & 干预措施
Mupirocin and Gentamicin
2% mupirocin ointments apply at exit-site once daily after wound cleaning before recruit in the study then use 0.1% gentamicin cream apply at exit-site once daily after wound cleaning after entry to the study.
干预措施: Mupirocin (Drug)
Mupirocin and Gentamicin
2% mupirocin ointments apply at exit-site once daily after wound cleaning before recruit in the study then use 0.1% gentamicin cream apply at exit-site once daily after wound cleaning after entry to the study.
干预措施: Gentamicin (Drug)
结局指标
主要结局
Rate of Exit-site infection in mupirocin compared with gentamicin group
时间窗: All exit-site infection episodes occurred last year in mupirocin group and all exit-site infection episodes have occurred after apply 0.1% grntamicin cream for 1 year.
Exit-site infection diagnosis by physician. Retrospective data collection from patient's medical records in mupirocin group Prospective data collection from patient's medical records in gentamicin group.
Rate of Infectious peritonitis in mupirocin compared with gentamicin group
时间窗: All infectious peritonitis episodes occurred last year in mupirocin group and all infectious peritonitis episodes have occurred after apply 0.1% grntamicin cream for 1 year.
Infectious peritonitis diagnosis by physicians. Retrospective data collection from patient's medical records in mupirocin group Prospective data collection from patient's medical records in gentamicin group
次要结局
- Number and percentage Causative pathogens of Infectious peritonitis in mupirocin compared with gentamicin group(All pathogenic organisms of infectious peritonitis episodes occurred last year in mupirocin group and all pathogenic organisms of infectious peritonitis episodes have occurred after apply 0.1% grntamicin cream for 1 year.)
- Percentage of catheter removal due to peritoneal dialysis-related infection(Retrospective period at least 1 year before recruit to the study, Prospective period at least 1 year after entry to the study.)
- Time to first peritoneal dialysis-related infection after gentamicin application(Prospective period at least 1 year after entry to the study.)
- Drug susceptibility of causative pathogens of peritoneal dialysis-related infection(Retrospective period at least 1 year before recruit to the study, Prospective period at least 1 year after entry to the study.)
- Number and percentage Causative pathogens of Exit-site infection in mupirocin compared with gentamicin group(All pathogenic organisms of exit-site infection episodes occurred last year in mupirocin group and all pathogenic organisms of exit-site infection episodes have occurred after apply 0.1% grntamicin cream for 1 year.)