Assessment of the Antibacterial Effect and Post-operative Pain Following Various Techniques of Intracanal Heating of Sodium Hypochlorite: A Randomized Clinical Trial
试验速览
- 阶段
- 1 期
- 状态
- 尚未招募
- 入组人数
- 36
- 主要终点
- Bacterial reduction
研究概览
简要总结
The goal of this clinical trial is to is to assess the antibacterial effect of sodium hypochlorite heated inside root canals of necrotic teeth using various activation techniques
The main question it aims to answer is:
Does the antibacterial effect vary following various standardized techniques of intracanal heating of sodium hypochlorite in endodontic treatment?
详细描述
Root canal treatment success depends on the removal of necrotic and vital pulp tissues and bacteria and bacterial byproducts from the root canal system.
Mechanical cleansing and removal of necrotic or vital pulp tissue lead to the formation of a layer of debris called " Smear layer," which is made of organic and inorganic substances that should be removed from the root canal system with the help of irrigants.
The presence of complex anatomy like isthmi and anastomoses makes chemical cleansing of the root canal system difficult because they are filled with the smear layer.
The ideal features of root canal irrigants include cleansing, lubrication of endodontic instruments and root canal system, dissolution of inorganic and organic tissues, antimicrobial properties, absence of cytotoxicity without alteration of dental microstructure. Sodium hypochlorite (NaOCl) has been the most widely used irrigant in endodontics due to its antimicrobial and tissue-dissolving action.
Due to the presence of complex anatomy inside the root canal system, activation of irrigation is essential to improve the cleaning of such a complex system. Ultrasonic activation is presently the most popular method for activation of irrigation. It delivers the irrigant farther into areas of the root canal system untouched by instruments, and it improves the mechanical cleaning by increasing the wall shear stress.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •For patients:
- •adult male or female patients
- •medically free.
- •For selected teeth:
- •asymptomatic necrotic single rooted teeth
- •teeth with mature root
- •restorable teeth.
排除标准
- •For patients:
- •Patients with dental related symptoms
- •patients with chronic or systemic diseases
- •pregnant females.
- •For selected teeth:
- •multirooted teeth
- •vital teeth
- •teeth with incompletely formed roots
- •teeth with internal or external resorption
- •previously root canal treated teeth
研究组 & 干预措施
Intracanal heating for activation using System-B heat carrier
干预措施: System-B (Device)
Intracanal heating for activation using ultrasonics
干预措施: Ultrasonic activation (Device)
Intracanal heating for activation using a combination of ultrasonics and System-B
干预措施: System-B (Device)
Intracanal heating for activation using a combination of ultrasonics and System-B
干预措施: Ultrasonic activation (Device)
结局指标
主要结局
Bacterial reduction
时间窗: after treatment, samples are sent to microbiology lab and bacterial count is measured day 1 after treatment.
Antibacterial effect is evaluated by counting number of bacterial colonies, samples are collected and placed in brain-heart infusion (BHI) broth and subjected to microbiological analysis to determine the colony-forming unit (CFU)/ml
次要结局
- Post-operative pain(Post operative pain is measured until day 3 after treatment)
研究者
Alaa El din Yasser Mohamed Salah Eldin
Dr
Misr University for Science and Technology
