A randomized, multicenter non-inferiority trial of 1-day versus 3-day dexamethasone in combination with palonosetron for prevention of nausea and vomiting induced by moderately emetogenic chemotherapy

Phase 3

• Conditions: colorectal cancer, lung cancer, breast cancer

• Registration Number: JPRN-UMIN000009403
• Lead Sponsor: Hokkaido University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-11-27
• Study Completion: 2013-03-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

Not provided

Exclusion Criteria

1)Serious or uncontrolled complication 2)Symptomatic or clinically suspected bone metastasis 3)Convulsive disorder needs anti-convulsant 4)Ascites fluid or pleural effusion needs paracentesis 5)Gastrointestinal obstruction 6)Vomiting and/or grade 2 or more nausea before chemotherapy 7)Hypersensitivity for 5-HT3 receptor antagonist 8)Hypersensitivity for dexamethasone 9)Pregnancy, lactation or who does not wish to contraception 10)History of palonosetorn administration 11)Capability or intention of cooperating 12)Participant in other anti-emetic trial 13)Undersirable for the patient to enter the trial

Study & Design

• Study Type: Interventional
• Study Design: Not specified