The Effect of Testosteron Replacement Treatment on the Fibroblast Growth Factor-23, Asymmetric Dimethylarginine and Vitamin D Levels in the Congenital Hypogonadotropic Hypogonadism
- Registration Number
- NCT02111473
- Lead Sponsor
- Gulhane School of Medicine
- Brief Summary
The study is designed to answer the following questions:
1) What is the effect of testosteron replacement treatment on the endothelial dysfunction.
2/ What is the effect of testosteron replacement on the bone mineral metabolism.
- Detailed Description
this is an interventional study which is examine the effect of testosteron replacement treatment on the endothelial dysfunction and bone mineral metabolism in hypogonadotropic hypogonadal patients.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 49
- Men
- Congenital hypogonadism
- Treatment Naive
- Previous history of androgen replacement
- Hypertension
- Diabetes mellitus
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description testosterone Testosterone testosterone 250 mg injection per 3-4 weeks for 6 months
- Primary Outcome Measures
Name Time Method the effect of testosteron replacement treatment on the Fibroblast Growth Factor-23. 6 months Plasma FGF-23 levels were determined by ELISA, (Human Intact FGF-23 ELISA Kit, Inc., San Clement, CA, USA).
the effect of testosteron replacement treatment on the asymmetric dimethylarginine. 6 months Plasma ADMA levels were determined by ELISA (Immunodiagnostic, Bernheim, Germany)
the effect of testosteron replacement treatment on the vitamin D levels. 6 months. Plasma 25-OH vitamin D3 levels were measured by Immuchrom kits (Hessen, Germany) using isocratic HPLC method with UV detector in Prominence HPLC system.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Gulhane School of Medicine
🇹🇷Ankara, Turkey