Postoperative Analgesia in Patients Undergoing Total Abdominal Hysterectomy: A Randomized Controlled Comparison Between Ultrasound Guided Erector Spinae Plane Block and Intrathecal Morphine
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- The time for requirement of first rescue analgesic (min)
研究概览
简要总结
Total abdominal hysterectomy (TAH) is a major surgical procedure after which significant post-operative pain and discomfort are anticipated. Abdominal field blocks have been followed for many years and extensively used for pain management following abdominal surgeries such as laparotomies and appendicectomies. Erector Spinae Plane Block (ESPB)-first recently described for the treatment of thoracic neuropathic pain, is a peri-paravertebral regional anesthesia technique that has since been reported as an effective technique for prevention of postoperative pain in various surgeries. Intrathecal opioid administration is an attractive analgesic technique since the opioid is injected directly into the cerebrospinal fluid, close to the structures of the central nervous system where the opioid acts.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 40 Years 至 55 Years(Adult)
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Body mass index (BMI) 25 to 35kg/m².
- •American Society of Anesthesiologist (ASA) physical status I or II.
排除标准
- •patient's refusal
- •Altered mental status
- •Known allergy to study drugs (bupivacaine or morphine)
- •Local infection at site of puncture.
- •Known case with any pulmonary disease
- •Known case with Obstructive sleep apnea (OSA)
- •Coagulopathy and /or thrombocytopenia
- •Chronic pain
- •Severe hepatic or kidney impairment
研究组 & 干预措施
G1 Group: (Erector Spinae Plane Block (ESPB) Group)
干预措施: Ultrasound Guided Erector Spinae Plane Block (Procedure)
G2 Group: (Intra thecal morphine (ITM) Group)
干预措施: Intra thecal morphine. (Drug)
G3 Group: (Control Group)
干预措施: General anesthesia using intravenous fentanyl (1µgm/kg) (Drug)
结局指标
主要结局
The time for requirement of first rescue analgesic (min)
时间窗: 24 hours postoperatively
The time for requirement of first rescue analgesic (min)
次要结局
未报告次要终点
研究者
Ibrahim Mamdouh Esmat
Assistant Professor of Anesthesia and Intensive Care Department, Faculty of Medicine, Ain-shams University, Cairo, Egypt.
Ain Shams University
