Short-term Automated Longitudinal Analysis of Speech and Language in Cognitive Impairment

Not Applicable

• Conditions: Dementia; Mild Cognitive Impairment

• Registration Number: NCT05340218
• Lead Sponsor: Accexible

Brief Summary

Validate speech analysis AI models:

* To contrast the accuracy of acceXible's platform as a screening tool in the detection of people with cognitive impairment and mild dementia.

* To evaluate the correlation between automatically analyzed linguistic variables and a combination of standard measures of cognition.

* To assess short-term variability in language ability among older adults, and to assess which aspects of language vary during the study period.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-01-01
• Primary Completion: 2019-12-01
• Status Verified: 2022-03
• Study First Submitted: 2022-03-29
• Study First Submitted QC: 2022-04-19
• Last Update Submitted: 2022-04-19
• Study First Posted: 2022-04-22
• Last Update Posted: 2022-04-22
• Study Completion: 2022-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Adult patients 55+ years of age with suspected MCI or diagnosis of dementia and obtains a score greater than 20 on the MMSE.
• Patients must have agreed to participate in the study and have voluntarily signed the informed consent.
• (Healthy) Participants without a diagnosis neurological, or psychiatric disorders. Or taking medication that can affect cognitive abilities.

Exclusion Criteria

• To have received a diagnosis of a significant psychiatric disorder or other cognitive impairment not due to neurodegeneration.
• To have significant vision problems that would affect the ability to perceive visual stimuli.
• To have significant hearing problems that would affect the ability to understand verbal cues.

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Pre-post variability of normal, MCI and dementia at both points of the study.	Change from the baseline cognitive function at 9 months.	Through standard deviation of normal subjects, MCI and dementia, variations in language are measured by considering MMSE scores and the most significant variables of accexible's tests (image description test, phonetic verbal fluency test and semantic verbal fluency test).

Secondary Outcome Measures

Name	Time	Method
Correlation between cognitive tests and language variables obtained by the platform.	Every 6 to 9 months	Correlation between: Standard measures of cognition (e.g., MMSE score) + behavioral and psychiatric symptoms of mild cognitive impairment and language.

Trial Locations

Locations (1)

Centro de Prevención de Deterioro Cognitivo; 🇪🇸 Madrid, Spain