Effect of lignocaine infusion and pain relief

Completed

• Conditions: Chronic cholecystitis, (2) ICD-10 Condition: K36||Other appendicitis,

• Registration Number: CTRI/2020/06/025839
• Lead Sponsor: Vinayaka Missions Research Foundation

Brief Summary

Ninety adult patients of either sex undergoing elective laparoscopic surgeries for appendicectomy or cholecystectomy will be recruited for this trial. Informed written consent will be obtained after satisfying inclusion criteria. They will be randomised into three groups of thirty each, all groups general anesthesia using standard protocol 9propofol 2mg/kg, fentanyl 0.002mg/kg, vecuronium 0.1mg/kg followed by endotracheal intubation; maintenance with 50:50 oxygen, nitrousoxide and sevoflurane 1.5MAC). Group L will receive 1.5mg/kg bolus folllowed by 1.5mg/kg/hour infusion of lignocaine, group P will receive normal saline infusion and Group D will receive dexmedetomidine bolus 1ug/kg followed by 0.5ug/kg/hour infusion during the intraoperative period. All infusions will be stopped during skin closure and following parameters will be observed : intraoperative pulse rate, blood pressure, post operative VAS scores and analgesia consumption during first 24 hours. statistical analysis will be done using appropriate tests.

Detailed Description

Not available

Study Timeline

• Study Completion: 2020-01-23
• Study Start: 2020-06-22
• Last Update Posted: 2021-02-27

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

American society of Anesthesiologists physical status 1 and 2, BMI 22-30kg/m2,.

Exclusion Criteria

ASA physical status 3 and 4 Emergency surgery, significant cardiac, respiratory and neurological illness, patients on chronic antiarrythmic drugs, psychotropic drugs, allergy to local anesthetics.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
post operative VAS score	0 min, 15 min, 30 min, 1 hour, 2 hour, 6 hour,12 hour, 24 hour

Secondary Outcome Measures

Name	Time	Method
Analgesia consumption (inj diclofenac, inj tramadol)	Hourly till 6 hours, 4th hourly till 24 hours
intraoperative heartrate and blood pressure	every 5 minutes throughout surgery

Trial Locations

Locations (1)

Vinayaka Misisons medical college; 🇮🇳 Karaikal, PONDICHERRY, India

Vinayaka Misisons medical college

🇮🇳Karaikal, PONDICHERRY, India

Prof Prasanna vadhanan

Principal investigator

9486489690

vadhanan.prasanna@gmail.com