Effect of Calanus Oli on Intra-abdominal Fat, Glucose Tolerance and Lipids in Man
Phase 2
Completed
- Conditions
- Overweight
- Interventions
- Dietary Supplement: calanus oilDietary Supplement: olive oil
- Registration Number
- NCT01193543
- Lead Sponsor
- University of Tromso
- Brief Summary
Preliminary studies in rats and mice indicate that calanus oil reduce accumulation of intra-abdominal fat. Pilot studies in humans have shown no adverse effects. In the present study 120 subjects, males and females, 20-65 years old, BMI 25-30 kg/m2 will be included and given calanus oli 1 g twice daily versus placebo for 1 year. The hypothesis is that calanus oil will reduce intra-abdominal fat, improve glucose tolerance and lipid profile.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 117
Inclusion Criteria
- Body Mass Index (BMI) 25-30 kg/m2
- age 20-65 years
Exclusion Criteria
- diabetes
- coronary heart disease last 12 months
- unstable angina pectoris
- cancer diagnosed the last 5 years
- use of lipid lowering drugs
- seafood allergy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description calanus oil calanus oil calanus oil 1 gram twice daily olive oil olive oil olive oil 1 gram twice daily
- Primary Outcome Measures
Name Time Method Intra-abdominal fat as measured with CT scan at the end of 12 months intervention
- Secondary Outcome Measures
Name Time Method oral glucose tolerance test at the end of 12 months intervention lipid status at the end of 12 months intervention systolic and diastolic blood pressure at the end of 12 months intervention markers of inflammation - C-reactive protein (CRP) at the end of 12 months intervention body weight at the end of 12 months intervention
Trial Locations
- Locations (1)
University of Tromso
🇳🇴Tromso, Norway