Analysis of Soluble Mediators,Cytokines and FACs as Prognostic Factors in Advanced Non-squamous Lung Carcinoma
- Conditions
- Non-small Cell Lung Cancer
- Registration Number
- NCT03156868
- Lead Sponsor
- Spanish Lung Cancer Group
- Brief Summary
Recent studies have shown that the assessment of a set of cytokines and / or circulating angiogenic factors (FACs) could be used to identify prognostic factors predictive of efficacy and / or potential mechanisms of resistance to antiangiogenic agents
- Detailed Description
Current management of patients with locally advanced or metastatic NSCLC, with no susceptible molecular alterations (EGFR mutation, ALK translocation, ROS1 fusion), includes combinations based on platinum in the first line of treatment, while in the second Line, there are three possibilities in monotherapy: docetaxel, erlotinib and pemetrexed. Pemetrexed is exclusively indicated for patients with a NSCLC of non-squamous histology. Although all of them have been shown to increase progression-free survival (PFS) and overall survival (OS), the median time to progression is maintained at 3 months, and the median overall survival at 8-9 months.
Recently, other therapeutic options have been incorporated in the context of the second line. Firstly, two antiangiogenic drugs: nintedanib and ramucirumab. The combination of nintedanib or ramucirumab with docetaxel in the second line of treatment has been shown to provide a significant increase in SLP and SG compared to docetaxel (9,11). One of the criticisms of the results of these two trials, common to all antiangiogenic treatments, is the lack of predictive factors that help us to better select the patients who would benefit from such treatment, as well as a better rationalization of Economic costs. On the other hand, recent data from new strategies based on immunotherapies in lung cancer indicate that nivolumab, a PD-1 antibody (Programmed cell death-1), has shown benefit in terms of survival versus docetaxel monotherapy both in Histology as squamous adenocarcinoma after failure to a platinum-based prior line.
Based on the above, the objective of this project is to analyze a panel of soluble mediators by means of multiparametric immunoassay techniques in samples of peripheral blood (at baseline, during treatment, and progression of the disease) obtained from patients With advanced lung adenocarcinoma, without molecular alterations treatable with anti-target drugs, that have progressed to a first line of chemotherapy, irrespective of whether they have received treatment with immunotherapies, and that they will be treated in the second line with chemotherapy (docetaxel) In combination or not with an antiangiogenic. It is a question of analyzing markers or panels of them with a prognostic / predictive meaning, as well as those that could be related to mechanisms of resistance to the administered treatments.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 153
- Patients aged ≥ 18 years
- Histological and / or cytological confirmation of non-squamous pulmonary carcinoma, stage IIIB / IV or recurrent
- Failure to a first line of chemotherapy for advanced or recurrent disease. Patients who have received 2 treatment lines will also be included and this will be the 3 rd line provided that during one of the previous lines they have received immunotherapy or antidandial therapies (in patients with a wild type or unknown mutational status).
- ECOG 0 or 1
- Life expectancy greater than 12 weeks.
- Written informed consent of the patient in accordance with current regulations
- Receive more than one line of chemotherapy treatment for advanced disease
- Hepatic function (one or more of the following values would exclude the patient): a. Total bilirubin outside the limits of normality; B. For patients without hepatic metastasis: ALT or AST> 1.5 times ULN; C. For patients with hepatic metastases: total bilirubin outside the limits of normality, ALT or AST> 2.5 times the ULN.
- Hemogram (one or more of the following values would exclude the patient): a. Absolute neutrophil count <1,500 / mm3; B. Platelets <100,000 / mm 3; C. Hemoglobin <9.0 g / dl.
- Situations such as the following: a. Active serious infections, especially if they require antimicrobial or systemic antibiotic treatment, or active or chronic infection with hepatitis C or B virus; B. Severe disease or non-oncological concomitant disease such as neurological, psychiatric or infectious disease or active ulcers (digestive tract, skin) or relevant analytical abnormality; C. Patients who are sexually active and do not want to use a medically acceptable method of contraception during the study and for at least 3 months after the completion of active treatment; D. Psychological, family, sociological or geographical factors; and. Alcoholism or current drug addiction; F. Preexisting ascites and / or clinically significant pleural effusion; G. Decompensated diabetes mellitus or other contraindication to treatment with corticosteroids at high doses
- Pregnancy or breastfeeding; The women must have obtained a negative result in a pregnancy test before starting the treatment
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Soluble mediators in relation to progression free survival At time of progression, an average of 1 year to correlate soluble mediators at progression time
- Secondary Outcome Measures
Name Time Method Soluble mediators in relation to response rate at time of first response, an average of 3 months the soluble mediators will be measured in the blood sample at time of first response
Trial Locations
- Locations (25)
Hospital General de Catalunya
🇪🇸Sant Cugat Del Vallès, Barcelona, Spain
Clínica Universitaria de Navarra
🇪🇸Pamplona, Navarra, Spain
ICO-Badalona
🇪🇸Badalona, Barcelona, Spain
Hospital de La Santa Creu I Sant Pau
🇪🇸Barcelona, Spain
Hospital de Torrevieja
🇪🇸Torrevieja, Alicante, Spain
Hospital Universitari Quirón Dexeus
🇪🇸Barcelona, Spain
Hospital de Jaén
🇪🇸Jaén, Spain
Hospital Sant Pau i Santa Tecla
🇪🇸Tarragona, Spain
Complejo Hospitalario Universitario Insular de Gran Canaria
🇪🇸Las Palmas de Gran Canaria, Gran Canaria, Spain
Hospital Son Llàtzer
🇪🇸Palma De Mallorca, Mallorca, Spain
Hospital Nuestra Señora Candelaria
🇪🇸Santa Cruz de Tenerife, Spain
H. Clínico San Carlos
🇪🇸Madrid, Spain
Consorci Sanitari de Terrassa
🇪🇸Terrassa, Barcelona, Spain
Hospital Severo Ochoa
🇪🇸Leganés, Madrid, Spain
Hospital Universitario de la Ribera
🇪🇸Alzira, Valencia, Spain
H.U. Puerta de Hierro
🇪🇸Madrid, Spain
Hospital de Elche
🇪🇸Elche, Alicante, Spain
H.G.U. Alicante
🇪🇸Alicante, Spain
Hospital Lucus Agustí
🇪🇸Lugo, Spain
Hospital Costa del Sol
🇪🇸Marbella, Málaga, Spain
Hospital Dr. Peset
🇪🇸Valencia, Spain
H. Provincial de Castellón
🇪🇸Castelló, Spain
Hospital Clinico de Salamanca
🇪🇸Salamanca, Spain
H. General U. de Valencia
🇪🇸Valencia, Spain
Hospital de Sagunto
🇪🇸Valencia, Spain