Platelet PAR-1 Activation in Health and Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Platelet Activation
研究概览
简要总结
Platelet activation has been associated with bad events like heart attack and stroke. There are a variety of platelet activators that regulate how active a platelet is. We are interested in Protease-activated receptors (PAR)-1. We are currently studying PAR-1 activation in persons with severe peripheral artery disease. We seek, through this project, to understand PAR-1 activation in persons without peripheral artery disease. As many patients with peripheral artery disease have diabetes, we will also evaluate PAR-1 activation in persons with type 2 diabetes. In addition we will assess the impact of the glucagon-like peptide (GLP)-1 signaling pathway on platelet activation. Levels of platelet activation will be determined using platelet aggregation experiments and assessment of platelet-monocyte aggregates in peripheral blood.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy men and women ≥60 years of age OR
- •Type 2 diabetic men and women ≥60 years of age
排除标准
- •Active cancer
- •Prior myocardial infarction, prior stroke, diagnosed peripheral artery disease
- •Severe liver (cirrhosis, cancer, or end-stage liver disease), kidney disease (eGFR <30 cc/min).
- •Pregnancy or lactation
- •Active vasculitis
- •Anticipated lifespan < 2 years
- •Current use of a DOAC
结局指标
主要结局
Platelet Activation
时间窗: One day
Number of dilysyl-MDA cross-links formed in human platelets
Protease Activated Receptor-1 Activation
时间窗: One day
Number of cleaved PAR-1 receptors in proportion to number of uncleared PAR-1 receptors
次要结局
未报告次要终点
研究者
Joshua Beckman
Professor
Vanderbilt University Medical Center