Effects of Oxytocin on Hemodynamics in Patients Undergoing Laparoscopic Myomectomy
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Changes of volume management parameters after oxytocin use during laparoscopic hysteromyomectomia.
研究概览
简要总结
This project will study the effect of oxytocin on hemodynamics in patients undergoing laparoscopic myomectomy, and how to prevent and manage such hemodynamic changes effectively.It provides a reference for the rational use of oxytocin in clinical practice, which can not only effectively contract the uterus and reduce bleeding, but also reduce the influence on hemodynamics.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •General anesthesia for gynecological laparoscopic surgery,ASA I~III
排除标准
- •Oxytocin use contraindications
研究组 & 干预措施
group 2 with oxytocin 10 U IM + oxytocin 10 U IV
干预措施: Oxytocin (Drug)
group 3 with oxytocin 20 U IM + oxytocin 0 U IV
干预措施: Oxytocin (Drug)
group 4 with oxytocin 0 U IM + oxytocin 20 U IV
干预措施: Oxytocin (Drug)
结局指标
主要结局
Changes of volume management parameters after oxytocin use during laparoscopic hysteromyomectomia.
时间窗: "before induction", "before incision", "before oxytocin intramuscular injection", and "20 sec, 40 sec, 60 sec, 80 sec, 100 sec, 120 sec, 140 sec, 160 sec,180 sec after oxytocin intramuscular injection".
CO (l/min) was measured by a Mostcare hemodynamic monitor.
Changes of traditional hemodynamic parameters after oxytocin use during laparoscopic hysteromyomectomia.
时间窗: "before induction", "before incision", "before oxytocin intramuscular injection", and "20 sec, 40 sec, 60 sec, 80 sec, 100 sec, 120 sec, 140 sec, 160 sec,180 sec after oxytocin intramuscular injection".
HR (beats/min) was measured by a Mostcare hemodynamic monitor.
次要结局
未报告次要终点
研究者
Zhuan Zhang
Principal Investigator
Yangzhou University