Evaluation of Predictive Genetic Markers of Response to Biologic Therapies in Chronic Arthritis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 379
- 主要终点
- Proportion of responsive patients with a given polymorphism (%)
研究概览
简要总结
Use of genotyping for the optimization of treatment with biologics in chronic arthritis by looking for an association between certain alleles and response to treatment.
详细描述
Chronic arthritis in children and in adults represent a public health problem in number and difficulty of treatment. 30% of patients are non-responders and / or relapse upon discontinuation of treatment. Some of these treatments are not always well tolerated, sometimes with infectious complications including tuberculosis limiting the use of biological therapies. This study will validate a battery of genetic markers to predict responders biotherapy, determine the prognosis of patients, these treatments are reserved for the most severe forms, and thus improve the care of patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 3 Months 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients treated with biotherapy may be included in this study with all information necessary for regular medical consultations (filling specific monitoring by GPs questionnaires), physical therapists visits, occupational therapists, psychologists.. etc
排除标准
- •Patients treated with biological therapy for non rheumatic disease
- •Other inflammatory diseases such as Crohn's disease
- •Refusal to participate in the collection
结局指标
主要结局
Proportion of responsive patients with a given polymorphism (%)
时间窗: At the inclusion
次要结局
- Distribution of patients with a given biotherapy (%)(At the inclusion)
- Distribution of patients presenting a given polymorphism (%)(At the inclusion)