Comparison of Different Root Canal Disinfection Protocols for Bacterial Reduction in Teeth With Apical Periodontitis Using Two Analytical Microbiological Methods: a Randomized Clinical Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 1
研究概览
简要总结
Evaluate and compare the disinfecting efficacy of two supplementary antimicrobial protocols in teeth with apical periodontitis
详细描述
This study aims to evaluate and compare the disinfecting efficacy of two supplementary antimicrobial protocols in teeth with apical periodontitis: Er,Cr:YSGG laser activated irrigation and ultrasonic activation using a piezoelectric ultrasonic device (Dentsply International Inc., York, PA, USA) and Irrisafe tip (Satelec/Acteon, Merignac, France), comparing the detection of bacteria before and after instrumentation.
Secondary aims are to assess presence of bacteria before and after chemomechanical preparation using two microbiological methods:
- ATP level analysis using the Endocator device
- Quantitative PCR (qPCR) for total bacterial quantification.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult patients able to give informed consent and willing/able to comply with study procedures and follow-up.
- •Molar teeth indicated for endodontic treatment.
- •Teeth with intact pulp-chamber walls (no extensive coronal destruction).
- •Necrotic pulp confirmed by pulp testing.
- •Clinical and radiographic evidence of asymptomatic apical periodontitis.
排除标准
- •Immature teeth
- •Teeth with calcified or obliterated canals
- •Teeth with extensive coronal destruction
- •Teeth with previous endodontic treatment
- •Symptomatic apical periodontitis
- •Teeth with periodontal pockets greater than 4 mm
- •Patients who have received systemic antibiotics in the last 3 months
- •Patients with a history of diabetes or immune impairment
- •Pregnant patients
研究者
Stephen M. Lyon, D.D.S
Principal Investigator
State University of New York at Buffalo