Multiomics Profiling of CSF in Cardiac Arrest Survivors

Active, not recruiting

• Conditions: Cardiac Arrest (CA); Hypoxic-Ischemic Brain Injury; Post-Resuscitation Syndrome

• Registration Number: NCT07090577
• Lead Sponsor: Chungnam National University Hospital

Brief Summary

The goal of this observational study is to identify further pathophysiologic mechanism of secondary brain injury following cardiac arrest by using serial multiomics profiling of serum and cerebrospinal fluid (CSF) samples. The main question it aims to answer is:

A. The main question it aims to answer is: What are the dynamic molecular changes in serum and CSF that reflect the pathophysiological mechanisms of secondary brain injury after cardiac arrest? B. What are the differences in serum and CSF multiomic signatures between varying severities of cardiac arrest, and how are these differences associated with the underlying pathophysiological mechanisms of secondary brain injury?

Serum and CSF samples that have already been prospectively collected from participants and stored in the BioBank will be used for this analysis.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-07
• Study First Submitted: 2025-07-21
• Study First Submitted QC: 2025-07-21
• Last Update Submitted: 2025-07-21
• Study Start: 2025-07-22
• Study First Posted: 2025-07-29
• Last Update Posted: 2025-07-29
• Primary Completion: 2026-12-31
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Age ≥ 18 years old
• Out-of-hospital cardiac arrest (OHCA)
• Patients who have received post-resuscitation care including temperature control due to unconsciousness (Glasgow Coma Score < 8) after sustained ROSC.
• Patients who consented to the placement of lumbar catheter for storing cerebrospinal fluid and blood samples in a human biobank.

Exclusion Criteria

• Patients diagnosed with a central nervous system-related disease before cardiac arrest
• Patients who have undergone extracorporeal circulatory membrane oxygenation therapy
• Patients who died within 24 hours from post-resuscitation care

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Neurological outcome	after 6 months from return of spontaneous circulation	Cerebral Performance Category (CPC) score

Secondary Outcome Measures

Name	Time	Method
The Pittsburgh Cardiac Arrest Category (PCAC)	immediately after return of spontaneous circulation	Illness severity of cardiac arrest

Trial Locations

Locations (1)

Chungnam National University Hospital; 🇰🇷 Daejeon, Korea, Republic of