Erector Spinae vs TAP in Lower Abdominal Surgery
- Conditions
- Postoperative Pain
- Interventions
- Procedure: lower abdominal surgeryOther: Transversus abdominis plane blockOther: Erector spinae plane block
- Registration Number
- NCT04555993
- Lead Sponsor
- National Cancer Institute, Egypt
- Brief Summary
The aim of this study is to compare the analgesic effect and safety profile of erector spinae plane block with transverses abdominis plane block in controlling peri-operative pain for lower abdominal cancer surgery.
- Detailed Description
Pain triggers a complex biochemical and physiological stress response leading to impairment of pulmonary, immunological and metabolic functions. Opioids are the current gold standard drug for postoperative pain relief, however exposure to large doses lead to multiple side effects of varying significance such as nausea, vomiting, dizziness, constipation, respiratory depression, hypoventilation and sleep breathing disorders. Therefore strategies other than opioids are recommended without sacrificing proper and effective analgesia. Especially in cancer patients who are more susceptible to tolerance and addiction.
The Transversus Abdominis Plane (TAP) block, is a regional anaesthesia technique used effectively in laparotomies. Unilateral analgesia to the skin, muscles, and parietal peritoneum of the anterior abdominal wall will be achieved without affecting visceral pain, when the anterior rami of the lower six thoracic nerves (T7-T12) and the first lumbar nerve (L1) are blocked.
Erector spinae plane block (ESPB) was shown to be an effective analgesic option for different types of surgeries. It's relatively a simple block, drug is injected in the plane between the erector spinae muscle and the vertebral transverse process. Blocking the ventral and dorsal rami of spinal nerves on the paravertebral area distributed from T2-T4 to L1-L2 and gives good coverage to visceral pain. Owing to the lower risk of blood vessel damage and neural damage compared to the epidural or the paravertebral block.
Both blocks haven't been compared to each other in this type of surgery before.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 62
- Physical status ASA II.
- Age ≥ 18 and ≤ 65 Years.
- Cancer patients undergoing laparotomies for radical cystectomy or radical hysterectomy or low anterior resection (lower abdominal procedures).
- Patient is able to provide a written informed consent.
- Body mass index (BMI): > 20 kg/m2 and < 40 kg/m2.
- Age <18 years or >65 years.
- BMI <20 kg/m2 and >40 kg/m2.
- Known sensitivity to local anaesthetics and morphine.
- History of psychological disorders and/or chronic pain.
- Significant liver or renal insufficiency.
- Contraindication to regional anaesthesia e.g. local sepsis, preexisting peripheral neuropathies and coagulopathy.
- Patient refusal.
- Severe respiratory or cardiac disorders.
- Pregnancy.
- ASA III-IV.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Transversus abdomis plane block lower abdominal surgery Patients will receive Transversus abdomis plane block Erector spinae plane block lower abdominal surgery Patients will receive Erector spinae plane block. Transversus abdomis plane block Transversus abdominis plane block Patients will receive Transversus abdomis plane block Erector spinae plane block Erector spinae plane block Patients will receive Erector spinae plane block.
- Primary Outcome Measures
Name Time Method Total morphine consumption 24 hours The total amount of morphine which was consumed post-operatively measured in milligrams
- Secondary Outcome Measures
Name Time Method Intraoperative fentanyl consumption. intraoperative The total amount of fentanyl which was consumed during the surgery measured in milligrams
Trial Locations
- Locations (1)
National Cancer Institute
🇪🇬Cairo, Egypt