Transcriptomic Analysis of Incisional Hernia Based on High-throughput Sequencing Technology

Completed

• Conditions: Incisional Hernia; Extracellular Matrix Alteration

• Registration Number: NCT06366581
• Lead Sponsor: Fudan University

Brief Summary

This study included patients who underwent surgical treatment for incisional hernia and non-hernia conditions. Surgical specimens were collected for transcriptome sequencing to obtain the gene expression list. Then genes analyzed by Gene Ontology, protein interactions, and signaling pathway enrichment using the expression matrix.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-03-01
• Primary Completion: 2023-09-01
• Status Verified: 2024-03
• Study Completion: 2024-03-01
• Study First Submitted: 2024-03-07
• Study First Submitted QC: 2024-04-14
• Last Update Submitted: 2024-04-14
• Study First Posted: 2024-04-16
• Last Update Posted: 2024-04-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

1.18 to 75 years 2.diagnosed with incisional hernia 3.normal tumour markers 4.elective surgery patients.

Exclusion Criteria

1. patients with vital organ failure (heart liver, lung, kidney and others)
2. malignant tumors not been completely relieved by active treatment,
3. patients who have psychiatric diseases or comprehension disorders.
4. patients with metabolic disease involving connective tissue collagen.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
the gene expression list	2023.3-2023.9	the gene expression list

Trial Locations

Locations (1)

Hua Dong Hospital Affiliated to Fu Dan University; 🇨🇳 Shanghai, China