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Clinical Trials/NL-OMON49393
NL-OMON49393RecruitingPhase 4

Treatment considerations for the surgical therapy of peri-implantitis - Surgical considerations in treating peri-implantitis

niversitair Medisch Centrum Groningen0 sites0 target enrollmentStarted: TBDLast updated:
Conditions

Trial Snapshot

Phase
Phase 4
Status
Recruiting

Study Overview

Brief Summary

No summary available.

Study Design

Study Type
Interventional

Eligibility Criteria

Ages
18 to 99 (—)

Inclusion Criteria

  • - the patient is >=18 years of age;
  • - adult patients with at least one endosseous implant in the oral cavity with
  • clinical and radiographical evidence of peri-implantitis. Peri-implantitis is
  • defined as probing pocket depth (PPD) of >= 6mm in combination with bleeding on
  • probing (BOP) or suppuration on probing (SOP) and radiographic bone loss of
  • >=3mm after placing the definitive suprastructure;
  • - the implants have been in function for at least 2 years;
  • - the patient is capable of understanding and giving informed consent.

Exclusion Criteria

  • Exclusion criteria prior to pre-treatment:
  • - medical and general contra-indications for the procedure;
  • - a history of local radiotherapy to the head and neck region;
  • - pregnancy and lactation;
  • - uncontrolled diabetes mellitus (HbA1c <7% or <53 mmol/mol);
  • - use of intravenous bisphosphonates;
  • - known allergy to chlorhexidine, amoxicillin and/or metronidazole;
  • - significant contra-indications to the use of antibiotics due to other
  • - long-term use of anti-inflammatory drugs
  • - patient is incapable of performing basic oral hygiene measures as a result of
  • physical or mental disorders;
  • - implants with bone loss exceeding 2/3 of implant length or implants with bone
  • loss beyond the transverse openings in hollow implants;
  • - previous surgical treatment of the peri-implantitis lesions;
  • - chronic bronchitis or asthma.
  • Additional exclusion criteria after pre-treatment:
  • - no peri-implantitis remaining: minor bleeding on probing (< 20%), probing
  • pocket depth < 6mm, plaque < 20%;
  • - active periodontal disease at the remaining dentition (probing pocket depth >=
  • 6mm, bleeding on probing >= 20%) or insufficient oral hygiene (plaque >= 20%);
  • - use of antibiotics during the last 3 months.

Investigators

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