Imaging the retina for early diagnosis in Alzheimer's disease - I-READ

Vrije Universiteit Medisch Centrum0 个研究点目标入组 40 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•-Study cases: patients with alzheimer's disease fulfilling the National
•Institute of Neurological and Communicative Disorders and Stroke and the
•Alzheimer's Disease and Related Disorders Association (NINCDS/ADRDA) criteria.
•-Controls: age and gender matched controls with Subjective Memory
•Complaints(SMC) and/or AMD (Age related Macula Degeneration) and no evidence of
•amyloid pathology according to CSF or amyloid PET scan analysis.
•-Patients need to be fully capacitated and able to give informed consent
•themselves, with an mini-mental state examination (MMSE)-score of at least

•+ Subject with ophthalmological conditions:
•- Media opacities interfering with optimal imaging
•- Narrow angle (with risk of acute angle close glaucoma)
•- History of glaucoma, uveitis, retinal detachment, retinal dystrophy)
•- History of chronic illness, with chronic medication, like reuma, sarcoidosis,
•inflammatory bowel disease, diabetes mellitus
•- Recent ocular surgery within 6 months prior to study examinations
•- Any ocular surgery of the vitreous / retina (vitrectomy, retinal detachment,
•macular hole, pucker). Late stages of Age related Macular Degeneration (AMD) or
•extensive drusen in the retina
•+ MMSE <=16
•+SMC with Aβ-pathologie
•+ Multiple sclerosis, Parkinson's disease or other neurodegenerative diseases

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