NL-OMON50349
Recruiting
Not Applicable
Imaging the retina for early diagnosis in Alzheimer's disease - I-READ
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Alzheimer's disease
- Sponsor
- Vrije Universiteit Medisch Centrum
- Enrollment
- 40
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\-Study cases: patients with alzheimer's disease fulfilling the National
- •Institute of Neurological and Communicative Disorders and Stroke and the
- •Alzheimer's Disease and Related Disorders Association (NINCDS/ADRDA) criteria.
- •\-Controls: age and gender matched controls with Subjective Memory
- •Complaints(SMC) and/or AMD (Age related Macula Degeneration) and no evidence of
- •amyloid pathology according to CSF or amyloid PET scan analysis.
- •\-Patients need to be fully capacitated and able to give informed consent
- •themselves, with an mini\-mental state examination (MMSE)\-score of at least
Exclusion Criteria
- •\+ Subject with ophthalmological conditions:
- •\- Media opacities interfering with optimal imaging
- •\- Narrow angle (with risk of acute angle close glaucoma)
- •\- History of glaucoma, uveitis, retinal detachment, retinal dystrophy)
- •\- History of chronic illness, with chronic medication, like reuma, sarcoidosis,
- •inflammatory bowel disease, diabetes mellitus
- •\- Recent ocular surgery within 6 months prior to study examinations
- •\- Any ocular surgery of the vitreous / retina (vitrectomy, retinal detachment,
- •macular hole, pucker). Late stages of Age related Macular Degeneration (AMD) or
- •extensive drusen in the retina
Outcomes
Primary Outcomes
Not specified
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