Elimination of Antibiotics During Citrate-anticoagulated Continuous-veno-venous-haemodialysis
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Filter patency during day 1 - 2 - 3 of citrate anticoagulated CVVHD
研究概览
简要总结
Acute kidney injury (AKI) requiring renal replacement therapy is common in critically ill patients. The major causes of AKI are severe sepsis and septic shock requiring effective antibiotic treatment. Patients with sepsis on ICUs usually are haemodynamically instable so that renal replacement therapy is applied using continuous techniques. In recent years, the efficacy of renal replacement therapies has improved, namely by using regional citrate anticoagulation which improves filter lifetime and filter patency. At present, the extent of removal of antibiotic drugs using citrate-anticoagulated CVVHD in critically ill patients has not been investigated thoroughly. Thus, the investigators want to investigate
- whether and to what extent antibiotic drugs (piperacillin/tazobactam and imipenem/cilastatin) are removed during citrate-anticoagulated CVVHD per se
- whether filter patency during citrate-anticoagulated CVVD remains stable during a treatment period of 72 h
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Intensive care patients with acute kidney injury requiring continous renal replacement therapy with citrate-anticoagulation
- •Age > 18 y
排除标准
- •Pregnancy
- •Contraindications against citrate-anticoagulation or continous renal replacement therapy
结局指标
主要结局
Filter patency during day 1 - 2 - 3 of citrate anticoagulated CVVHD
时间窗: up to three days
Filter patency is calculated as a function of the sieving coefficient for small solutes (i.e. creatinine and the respective antibiotic drugs) over the first 72 h, Sieving coefficient is without dimension
Removal of antibiotic drugs during day 1 - 2 - 3 of citrate anticoagulated CVVHD (mg/d)
时间窗: up to three days
Total hemofilter clearance (ml/min) of imipenem/cilastatin and piperacillin/tazobactam on each treatment day during an 8-hour dosing interval using blood sided clearance - Total amount of antibiotic drug which is eliminated via the filter during 24 h using filter clearance and delivered dialysis dose during 24 h
次要结局
未报告次要终点
研究者
Klinik für Anästhesiologie
Prof. Dr. D. Kindgen-Milles
Heinrich-Heine University, Duesseldorf