Effects of Systemic Diseases and Medications on Eye and Artificial Intelligence Model Development: a Multi-center Epidemiological Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 1,000
- 主要终点
- morbidity
研究概览
简要总结
A variety of diseases in the Department of Rheumatology, Immunology, Nephrology, and Gastroenterology can cause eye lesions, and medications can also bring various adverse reactions, which can seriously reduce the quality of patients' daily life, bring additional economic burdens, and even threaten the lives of patients. This study aims to recruit patients from the aboved-mentioned departments and conduct a cross-sectional and cohort study. On one hand, we plan to compare the epidemiological characteristics of ocular lesions of systemic diseases and eye adverse drug effects in patients with rheumatology, immunology, nephrology and gastroenterology, and summarized some epidemiological indices such as prevalence, high-risk factors, etc. On the other hand, we plan to develop an artificial intelligence model after collecting certain case data. By selecting risk factors related to the occurrence of ocular lesions, we aim to train models that can predict the ocular manifestations of systemic diseases and medications.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Years 至 80 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 6-80 years old, gender is not limited
- •patients who have been diagnosed with systemic diseases;
- •patients who have ever or never used any ocular toxic drugs such as corticosteroids, chloroquine, etc.;
- •no history of glaucoma, cataract, scleritis, uveitis, ocular trauma, etc. before enrollment;
- •willing to complete follow-ups for at least 2 years.
排除标准
- •Mainly use local therapies (intraocular, intra-articular and other non-systemic drug routes);
- •history of intraocular surgery (such as lens implantation, vitrectomy, retinal photocoagulation);
- •history of glaucoma, cataract, center serous retinopathy, etc.;
- •history of various diseases (such as scleritis, uveitis, eye trauma, etc.) that may cause opacity of the eye under the posterior capsule;
- •any other diseases or conditions that affect the observation, such as diabetes, low calcium convulsions, long-term exposure to radiation before enrollment;
- •subjects with endogenous corticosteroids, or psychiatric diseases.
研究组 & 干预措施
ever user of systemic medications
干预措施: Corticosteroids, immunosuppressors, biological agents (Drug)
current user of systemic medications
干预措施: Corticosteroids, immunosuppressors, biological agents (Drug)
结局指标
主要结局
morbidity
时间窗: 2021.4.22-2025.4.22
Morbiditys of various ocular lesions.
次要结局
未报告次要终点
研究者
Haotian Lin
Vice President of Zhongshan Ophthalmic Center
Sun Yat-sen University