The Effect of Local Anesthetic Infiltration or Erector Spina Plan Block on Stress Hormone Response
- Conditions
- Erector Spinae Plane BlockInguinal HerniaPost Operative Pain
- Registration Number
- NCT05717530
- Lead Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
- Brief Summary
Laparoscopic cholecystectomy is one of the most common operations in abdominal surgery.
Effective analgesia in the postoperative period; It is of great importance in terms of acceleration of recovery, prevention of atelectasis, reduction of endocrine and metabolic stress response, reduction of thromboembolic complications, protection of cognitive functions, prevention of chronic pain development, and reduction of hospital stay . Intravenous paracetamol, NSAID/cyclooxygenase-2 selective inhibitors, opioids, local anesthetic infiltration in the port area, intraperitoneal local anesthetic insufflation or plan blocks can be used in the treatment of postoperative pain after laparoscopic cholecystectomy. Operation, tissue trauma, anesthesia, drugs given to the patient, type of anesthesia, blood loss, temperature changes and pain cause postoperative stress response
- Detailed Description
Laparoscopic cholecystectomy is one of the most common operations in abdominal surgery. Abdominal and shoulder pain are frequently seen in patients in the postoperative period.
Laparoscopic surgery is considered the gold standard in abdominal surgery because of its low cost, less postoperative pain, early mobilization, and short hospital stay. Effective analgesia in the postoperative period; It is of great importance in terms of acceleration of recovery, prevention of atelectasis, reduction of endocrine and metabolic stress response, reduction of thromboembolic complications, protection of cognitive functions, prevention of chronic pain development, and reduction of hospital stay . Intravenous paracetamol, NSAID/cyclooxygenase-2 selective inhibitors, opioids, local anesthetic infiltration in the port area, intraperitoneal local anesthetic insufflation or plan blocks can be used in the treatment of postoperative pain after laparoscopic cholecystectomy. In laparoscopic cholecystectomy operations, the results of pain reduction and analgesic consumption in incisional local anesthetics are variable.
Operation, tissue trauma, anesthesia, drugs given to the patient, type of anesthesia, blood loss, temperature changes and pain cause postoperative stress response .
In various surgeries, regional anesthesia for post-operative purposes, plan blocks, infiltration or insufflation methods were found to suppress the stress response.
In this study, the investigator aimed to compare the effects of local anesthetic infiltration at the wound site and erector spine plane block on stress hormone response and postoperative analgesia in patients who will undergo laparoscopic cholecystectomy surgery.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 90
- who will undergo laparoscopic cholecystectomy
- ASA (American Society of Anesthesiology) I-II
- 18-65 age group
- operated between 08:00-12:00 in the morning
- Pregnant,
- Diabetes Mellitus
- Emergency surgery
- ASA (American Society of Anesthesiology)III-IV
- Patients who did not consent to the study,
- History of local anesthetic allergy,
- Coagulation disorder,
- Morbid obesity (body mass index >40 kg/m²),
- Severe organ failure,
- Previous neurological deficit,
- Psychiatric disease,
- Patients with a history of chronic pain
- Who were switched to the open procedure due to surgical complications during the operation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Stress hormone response 5 hour Blood was taken and recorded in a yellow capped gel biochemistry tube (SSTTM II Advance Tubes) for the measurement of stress hormone glucose(70-100 mg/dl), prolactin(4.79-23.3µg/dL), and cortisol(60.2-184 µg/dL) 1 hour before and 1 hour after the operation.
- Secondary Outcome Measures
Name Time Method Analgesia period 24 hour The time from the end of the operation to the first analgesic requirement was determined as the "analgesia period" and this time was recorded.
Visual Analog Pain Scale 24 hour visual analog for pain consist of a horizontal line, usually 100 mm in length. the left end of the line signifies no pain which is depicted by a smiling face while the right end signifies the worst possible pain with a frowning face. this visual depiction of pain levels helps the patient to communicate about the intensity of their pain.
Trial Locations
- Locations (1)
Sisli Hamidiye Etfal Training and Research Hospital
🇹🇷Sisli, Istanbul, Turkey
Sisli Hamidiye Etfal Training and Research Hospital🇹🇷Sisli, Istanbul, Turkey