NL-OMON46094
Completed
Not Applicable
The influence of apical periodontitis on the concentration of inflammatory mediators in peripheral blood plasma and the metagenomic profiling of endodontic infections. - AP, health & metagenome
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- tandheelkundige infecties
- Sponsor
- Academisch Centrum Tandheelkunde Amsterdam
- Enrollment
- 60
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Intervention group
- •\- The subject is 18 \- 80 years old.
- •\-After intra\-oral examination, AP has been confirmed with an intra\-oral radiograph and appears on the radiograph as a radiolucent area around one or more root tips of the affected tooth. AP is diagnosed when in the periapical region, the periodontal ligament is at least twice as wide as in the mid\-root regions. A root canal treatment has a poor prognosis or the patient would rather have the affected tooth extracted. The AP tooth is non\-symptomatic.
- •\- No other teeth have AP. To confirm this, front teeth are clinically examined. Discoloured teeth or teeth with restorations that do not respond to cold testing or that are tender to percussion or palpation will also be examined with an intra\-oral radiograph. In the (pre)molar region, recent bite\-wing radiographs are used to screen for deep restorations or dental caries. When there are doubts about the vitality of restored or decayed (pre)molars an additional radiograph is taken.
- •\- The subject has completed the medical history questionnaire.
- •\- The subject wants to participate and donate six blood samples at six different time points and the subject wants to donate the extracted tooth. The subject has signed the IC letter.
- •\- The subject will not undergo dental hygienist\* treatments during the study.;Non\-intervention group
- •\- The subject is 18 \- 80 years old.
- •\- The subject has not had endodontic treatment in the past or previously root\-canal treated teeth show no signs or symptoms of AP.
- •\- The subject has completed the medical history questionnaire and is classified as healthy.
Exclusion Criteria
- •Intervention group
- •A potential subject who meets any of the following criteria will be excluded from participation in this study:
- •\- pregnancy or lactation
- •\- diabetes mellitus type I,
- •\- chronic inflammatory diseases like m. Crohn
- •\- use of antibiotics 1 month prior with an indication other than AP of the aimed tooth.
- •\- use of corticosteroids or NSAIDs
- •\- chemotherapy or previous head/neck irradiation
- •\- any surgery 6 months prior
- •\- any existing extra\-oral swelling
Outcomes
Primary Outcomes
Not specified
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