Registration and sample collection for identification of genetic and public health characteristics of the major birth defects in korea

Not Applicable

Completed

• Conditions: Congenital malformations, deformations and chromosomal abnormalities

• Registration Number: KCT0003671
• Lead Sponsor: Korea Centers for Disease Control and Prevention

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 23 April 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 1400

Inclusion Criteria

Pregnant woman who visits the site for prenatal examination and is diagnosed with congenital abnormalies in fetus and her fetus and husband

-Pregnant woman who visits the site for prenatal examination and is not diagnosed with congenital abnormalies in fetus detected by ultrasonography
-1:1 matching with pregnant women in case group based on their age, their pregnancy week number and gender of their fetus

Exclusion Criteria

- History of childbirth with chromosomal abnormalities
- Parents with balanced translocation carrier
- History of structural birth defects
- Birth abnormalies under prenatal ultrasonography
- Abnormalies in umbilical cord or placenta under prenatal ultrasonography
- History of administration of FDA preganacy Category D drug during pregnancy
- History of illegal drug use
- Maternal diseases potentially associated with fetal defects
- Birth defects discovered after delivery
- Family history of genetic diseases
- Pregnant women who are exposed to clinically harmful environment
- Low birth weight or high birth weight infant
- Pregnant women with abnormal BMI

Study & Design

• Study Type: Observational Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Relationship between environmental pollution and occurrence of congenital abnormalies

Secondary Outcome Measures

Name	Time	Method
Risk factors associated with congenital abnormalies