Aspiration of Excessive Endometrial Fluid at the Day of Ovum Retrieval Plus Diosmin in (ICSI) Cycles

Not Applicable

Completed

• Conditions: Infertility
• Interventions: Other: group A

• Registration Number: NCT02158000
• Lead Sponsor: Benha University

Brief Summary

To notify the effect of aspiration of excessive endometrial fluid in addition to Diosmin in cases undergoing intracytoplasmic sperm injection (ICSI) cycles.

Detailed Description

Objectives: To notify the effect of aspiration of excessive endometrial fluid in addition to Diosmin in cases undergoing intracytoplasmic sperm injection (ICSI) cycles.

Study design: Prospective randomized controlled clinical trial.

Patients and Methods: 200 women with excessive endometrial fluid by transvaginal ultrasound during ICSI cycles are randomly scheduled into two equal groups. In group A, one tab every 8 hs Diosmin ( 500mg) beginning from the day of ovum retrieval in addition to aspiration of the fluid by an IUI catheter ; while in group B (control group), no thing is given or done. The main outcome measures are presence of the fluid on the day of embryo transfer and the pregnancy rate on those patients.

Study Timeline

• Study Start: 2014-06
• Study First Submitted: 2014-06-05
• Study First Submitted QC: 2014-06-05
• Study First Posted: 2014-06-06
• Primary Completion: 2021-11
• Study Completion: 2021-11
• Status Verified: 2022-06
• Last Update Submitted: 2022-06-24
• Last Update Posted: 2022-06-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 200

Inclusion Criteria

• women with excessive endometrial fluid by transvaginal ultrasound during ICSI cycles

Exclusion Criteria

• none

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group A	group A	In group A , 100 women with excessive endometrial fluid by transvaginal ultrasound during ICSI cycles are allocated to receive one tab / 8 hs of Diosmin ( 500mg) beginning from the day of ovum retrieval and for 3 days (till the day of embro trasfer) in addition to aspiration of the fluid by an IUI catheter.

Primary Outcome Measures

Name	Time	Method
the pregnancy rate	is checked 16 days after embryos transfer	is assessed by :serum hCG test Beta sub-unit of hCG (serum hCG test)

Secondary Outcome Measures

Name	Time	Method
presence of the fluid on the day of embryo transfer	at the day of embryo transfer	detection of excessive endometrial fluid by transvaginal ultrasound during ICSI cycles

Trial Locations

Locations (1)

Benha univesity hospital; 🇪🇬 Banhā, El Qualyobia, Egypt