Cognitive Training for Post Traumatic Stress Disorder: Effects on Cognitive, Emotional, and Brain Function

Not Applicable

• Conditions: Posttraumatic Stress Disorders
• Interventions: Behavioral: Executive function training

• Registration Number: NCT01644851
• Lead Sponsor: University of Missouri, Kansas City

Brief Summary

The purpose of this pilot study is to determine the effects of computer-based training in executive functioning compared to word games on cognitive and emotional aspects of combat-related PTSD.

Detailed Description

Many posttraumatic stress disorder (PTSD) patients either choose not to complete or do not achieve optimal response to current first-line behavioral and pharmacologic treatments. Neurocognitive research points to the potential of novel treatments targeting dorsal prefrontal function and inhibition, attention, and working memory processes. This study investigates effects of computer-based training in executive functions compared to word games on cognitive and emotional aspects of combat-related PTSD. Paper-and-pencil questionnaires, interviews, computer-administered testing, and magnetic resonance imaging will be complete before and after the intervention. Results from this pilot study will provide information concerning feasibility and treatment potential of cognitive training for PTSD.

Study Timeline

• Study Start: 2012-07
• Study First Submitted: 2012-07-17
• Study First Submitted QC: 2012-07-18
• Study First Posted: 2012-07-19
• Status Verified: 2014-12
• Last Update Submitted: 2014-12-04
• Last Update Posted: 2014-12-08
• Primary Completion: 2015-07
• Study Completion: 2015-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 40

Inclusion Criteria

• combat veterans who served in Operation Iraqi Freedom, Operation Enduring Freedom, or Operation New Dawn

Exclusion Criteria

• enrolled in other active treatment protocols
• current substance abuse or dependence
• current suicidal ideation
• diagnosis of a neurological disorder
• history of moderate to severe traumatic brain injury

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Executive function training	Executive function training	Executive function training

Primary Outcome Measures

Name	Time	Method
Neural activity in prefrontal regions during cognitive and emotional processing measured by functional magnetic resonance imaging.	change from baseline to after 6 weeks of training

Secondary Outcome Measures

Name	Time	Method
Cognitive functioning as measured by neuropsychological assessment.	change from baseline to after 6 weeks of training

Trial Locations

Locations (1)

Univesity of Missouri - Kansas City; 🇺🇸 Kansas City, Missouri, United States