NL-OMON34060已完成3 期
Doxycycline versus minocycline in the treatment of rosacea: a randomized controlled trial. - DoMino
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 80
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •1. Subject is 18 years of age or older at baseline; both genders.
- •2. Subject has moderate to severe papulopustular rosacea, characterised by at least 8 lesions (papules and/or pustules), IGA higher than two and a CEA score higher than one, clinical confirmed by one of the investigators.
- •3. Subject has a negative urine pregnancy test at screening and uses a form of anticonception.
- •4. Subject can fill out a Dutch questionnaire or has a person willing to translate the questions in their own language.
- •5. Subject has voluntarily signed and dated an informed consent prior to any study related procedure and is willing to comply with the requirements of this study protocol which has been approved by an Institutional Review Board (IRB)/Independent Ethics Committee (IEC).
排除标准
- •1. Subject is pregnant, nursing, or planning pregnancy while enrolled in the study and until 3 months after discontinuation of the study.
- •2. Presence of dermatoses that might interfere with the rosacea diagnosis or the evaluation of treatment results.
- •3. The initiation of a hormonal method of contraception within 3 months of baseline; or discontinuation during the course of study; or change in the actual product within 3 months of baseline or during the study.
- •4. Known hypersensitivity/allergy to tetracycline*s.
- •5. Subject has used topical medications/treatments that could affect rosacea evaluation starting within 2 weeks of the first administration of study agent.
- •6. Subject has used systemic treatments (antibiotics, corticosteroids) for rosacea less than 4 weeks before baseline.
- •7. Subject has had facial laser-therapy less than 4 weeks before baseline or planned during study.
- •8. Subject has used any investigational drug within the previous 4 weeks or 5 times the half-life of the investigational agent prior to the first administration of study agent, whichever is longer.
- •9. Subject has used isotretinoin in the six months prior to randomization.
- •10. Subject is known to have hepatic impairment or to those receiving potentially hepatotoxic medicinal products.
- •11. Subjects is known to have, or is suspected to have, achlorhydria (production of gastric acid in the stomach is absent) or had surgery that bypasses or excludes the duodenum.
- •12. Current drug or alcohol abuse.
- •13. For any reason, subject is considered by the local investigator to be an unsuitable candidate to participate in this trial.
研究者
相似试验
进行中（未招募）
不适用
Doxycycline versus minocycline in the treatment of rosacea: a randomised controlled trial. - DoMino-studyPatients with moderate to severe, papulopustular rosacea.MedDRA version: 12.1Level: LLTClassification code 10039218Term: RosaceaEUCTR2010-021150-19-NLAcademical medical Center, Department of dermatology
尚未招募
2 期
Treatment of periodontal defects with a combination of autologous blood products and antibioticsCTRI/2024/07/070193DOGIPARTHI MOUNICA
已完成
3 期
Effect of low dose Doxycycline as an adjuct to non-surgical periodontal therapy on the serum level of inflammatory mediators and lipid profile in advanced periodontitisadvanced periodontitis disease.Chronic PeriodontitisIRCT138904071081N4Vice-Chancellor for Research, Guilan University of Medical Sciences40
尚未招募
2 期
Evaluation of the effectiveness of doxycycline in the treatment of outpatients with Covid-19IRCT20160523028008N16Hamedan University of Medical Sciences88
进行中（未招募）
不适用
To investigate the effect of a medicine called doxycycline in people with evidence of stiffening of the heart muscleDiastolic dysfunctionMedDRA version: 14.1Level: PTClassification code 10052337Term: Diastolic dysfunctionSystem Organ Class: 10007541 - Cardiac disordersEUCTR2010-021664-16-IESolvotrin Innovations Ltd60