Covid-19 during pregnancy - Histopathological lesions of the placenta
- Conditions
- U07.1COVID-19, virus identified
- Registration Number
- DRKS00032000
- Lead Sponsor
- Klinikum im Friedrichshain
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 75
Inclusion Criteria
inclusion criteria Covid-19 patient group:
a) Covid-19 infection during pregnancy
inclusion criteria control group:
a) gestational age 37 0/7 - 41 6/7 weeks of gestation
b) uncomplicated pregnancy
Exclusion Criteria
exclusion criteria Covid-19 patient group:
a) minor of age
b) not capable of consent
exclusion criteria control group:
a) minor of age
b) not capable of consent
c) gestational or pre-existing diabetes mellitus
d) placental insufficiency
e) gestosis
f) triple I
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method histoathological lesions of placental specimen concerning inflammation and hypercoagulopathy (pervillous fibrin deposit, infarction, intervillous thrombi, intervillositis)
- Secondary Outcome Measures
Name Time Method •number of vaginal delivery, vaginal operative delivery, cesarean section <br>•number of symptomatic Covid-19 infections<br>•number of severe Covid-19 infections<br>•number of placental insufficiency (defined as intrauterine growth restriction, oligohydramnios, abnormal fetal doppler ultrasound) <br>•number of late miscarriages<br>•number of intrauterine fetal death<br>•number of premature abruption of the placenta<br>•number of occurrence of preeclampsia<br>secondary criteria:<br>• maternal age<br>• maternal comorbidities<br>• gestational age at time of delivery<br>• gestational age at the time of the Covid-19 illness<br>• type of Covid-19 symptoms