Role of radiation therapy in advanced stage thyroid cancer

Phase 2

• Conditions: Health Condition 1: null- PATEINTS WITH LOCALLY ADVANCED NON METASTATIC THYROID CANCER IN GOOD GENERAL CONDITIO

• Registration Number: CTRI/2016/12/007585
• Lead Sponsor: Tata Memorial Hospital Intramural fundin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: Not specified
• Target Recruitment: 72

Inclusion Criteria

A) All patients of thyroid cancer (papillary/follicular/poorly differentiated) who have undergone total/completion thyroidectomy at our institute and having at least two of the following features (listed below) intra-operatively and/or on histopathology

1.Gross extrathyroidal spread into soft tissues of the neck, trachea, esophagus, recurrent laryngeal nerve (constituting stage T4a)

2.R1/ shave resections (minimal residual disease)

3.R2 resections (gross residual disease)

4.Multiple lymph nodes positive( >2) with perinodal extension at level VI

B) Normal baseline haematological and biochemical parameters

Exclusion Criteria

1.Anaplastic or medullary thyroid cancer

2.Previous history of radiation

3.Pregnancy

4. < 18 years

5.Patient unwilling to participate in the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
â?¢To assess the impact of adjuvant RT on loco-regional control in patients with locally advanced differentiated thyroid cancers who have undergone surgery with radioiodine therapyTimepoint: â?¢Assessment for locoregional recurrence will be done at every follow up upto five years after completion of treatment.

Secondary Outcome Measures

Name	Time	Method
â?¢To assess toxicity (early and late at 2 years) of adjuvant RT in these patientsTimepoint: at 2 years