Acute Effects of Partial Sleep Deprivation on Appetite, Energy Intake and Physical Activity
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 48
- 主要终点
- Energy intake
研究概览
简要总结
This study will investigate whether acute sleep deprivation affects appetite, eating behavior, and physical activity in both regular exercisers and physically inactive individuals.
详细描述
Prior to the main trials, participants will complete assessments of V̇O2max and maximal muscle strength within 7 to 14 days before the main trials. They will also record one week of daily physical activity, sleep patterns, and diet (including two weekdays and one weekend day) to ensure they meet the inclusion criteria.
Participants will be healthy males aged 20 to 45, grouped according to their habitual activity levels.
- Sedentary: fewer than 7,000 steps/day, no regular exercise in the past 6 months.
- Regular Aerobic Exercise: Running or cycling at least 2-3 times/week for the past 6 months.
- Regular Resistance Exercise: Engaging in resistance exercise at least 2-3 times/week for the past 6 months, with minimal aerobic training.
Day 1:
Physical activity is restricted to a minimum, with no exercise permitted. Participants are allowed to eat freely before 15:00; however, all food intake will be recorded to enable replication prior to the subsequent main trial. Napping is not permitted. Participants will arrive at the laboratory between 18:30 and 19:00. Subjective appetite sensations and food preferences will be assessed. Participants will have either an 8-hour sleep opportunity in the laboratory from 23:00 to 07:00 (i.e., normal sleep trial) or a 3-hour sleep opportunity from 03:00 to 07:00 (i.e., partial sleep deprivation trial).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Age between 20 and 45 years.
- •Body Mass Index (BMI) between 18.5 to 27 kg/m².
- •No sleep-related medical conditions and good sleep quality, defined as a Pittsburgh Sleep Quality Index (PSQI) score ≤
- •Usual bedtime between 22:00 and 01:00, wake-up time between 06:00 and 09:00, with an average sleep duration of 7 to 9 hours. Chronotype classified as "definitely not evening type" (score ≥ 42 on the Morningness-Eveningness Questionnaire), with no changes in sleep patterns over the past 3 months.
- •Without any metabolic or cardiovascular diseases, and not using medications that could affect metabolic responses.
- •No specific dietary habits, such as intermittent fasting or a ketogenic diet.
- •Maintaining a stable weight (no self-reported weight change greater than ±3 kg) for at least 3 months.
- •Resting blood pressure ≤ 130/80 mmHg.
- •No smoking or excessive alcohol consumption.
- •Not a shift worker.
- •No international travel across time zones in the past 3 months.
排除标准
- •Special diets (e.g., intermittent fasting, ketogenic diet)
- •Recent injuries or contraindications to intense exercise.
研究组 & 干预措施
Normal sleep
Participants will have an 8-hour sleep opportunity in the lab from 23:00 to 07:00.
干预措施: Normal sleep (Behavioral)
Partial sleep deprivation
Participants will have a 3-hour sleep opportunity in the lab from 03:00 to 07:00.
干预措施: Partial sleep deprivation (Behavioral)
结局指标
主要结局
Energy intake
时间窗: 4 days in a free-living conditions.
Energy and macronutrients intake will be collected using pictures and via a food scale
Physical activity
时间窗: 4 days in a free-living conditions.
Physical activity level and intensity will be collected using wearable devices
次要结局
- Food preference(Baseline and at the end of the 3-hour oral glucose tolerance test (OGTT).)
- Appetite sensations(At 0 (baseline), 30, 60, 90, 120, 150, and 180 minutes during the 3-hour oral glucose tolerance test (OGTT).)
- Mood sensations(At 0 (baseline), 30, 60, 90, 120, 150, and 180 minutes during the 3-hour oral glucose tolerance test (OGTT).)
- Sleep sensations(At 0 (baseline), 30, 60, 90, 120, 150, and 180 minutes during the 3-hour oral glucose tolerance test (OGTT).)
- Sleep(4 days in a free-living conditions.)
- Glucose responses(4 days in a free-living conditions.)
研究者
Yung-Chih Chen
Principal Investigator
National Taiwan Normal University