The Post Anaesthesia N-Acetycysteine Cognitive Evaluation trial, investigating the potential for N-Acetylcysteine to reduce cognitive dysfunction following major elective non-cardiac surgery

Phase 2

Recruiting

• Conditions: Post surgical pain; Mental Health - Studies of normal psychology, cognitive function and behaviour; Post Operative Cognitive Dysfunction; Surgical Stress Response; Post Operative Mood Disorder; Anaesthesiology - Anaesthetics; Surgery - Other surgery

• Registration Number: ACTRN12614000411640
• Lead Sponsor: The Geelong Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-04-15
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 370

Inclusion Criteria

Patients above the age of 60 years undergoing major elective non cardiac surgery, defined as surgery expected to last at least 1 hour in duration and requiring admission to hospital.

Exclusion Criteria

Participants will be ineligible to take part if they;
* Have known contraindications to NAC including allergies and concomitant nitrate therapy
* Are unable to comply with the requirements of informed consent or the study protocol
* Are already taking NAC
* Require subsequent procedures necessitating general anaesthesia prior to completion of testing procedures
* Are undergoing carotid endarterectomy, due to the high incidence of perioperative cerebrovascular accidents
* Experience major perioperative morbidity, or mortality, that precludes them from completing post-operative cognitive testing within the prescribed time frame.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
A between-groups difference in the severity of early Post-operative Cognitive Dysfunction (POCD) as measured by the psychomotor-attention composite score of the CogState Brief Battery, adjusted for baseline values. [Post Operative Day 7]