Effect of Low GI/ Glycemic Load (GL) Diet in Diabetic Nephropathy Patients

Not Applicable

Completed

• Conditions: Diabetic Nephropathy; Medication Compliance
• Interventions: Other: low GI; Other: conventional diet

• Registration Number: NCT02384902
• Lead Sponsor: Isfahan University of Medical Sciences

Brief Summary

low GI and low GL diet have more beneficial effect for diabetic nephropath patients compared with conventional diet.

low GL may have more favorable effect than low GI diet.

Detailed Description

According to body weight status of participants, the investigators considered a slight calorie restriction ranged from 200 to 300 Kcal/d. Planed meals and exchange list prescribed for all volunteers. Dietary records forms were given to all subjects and they were educated how to record their dietary intakes. The investigators asked subjects not to change their physical activity level during the study and monitored them for their physical activity level by 3 days physical activity records monthly.

Study Timeline

• Study Start: 2014-05
• Primary Completion: 2014-07
• Study Completion: 2014-07
• Study First Submitted: 2014-09-06
• Status Verified: 2015-03
• Study First Submitted QC: 2015-03-09
• Last Update Submitted: 2015-03-09
• Study First Posted: 2015-03-10
• Last Update Posted: 2015-03-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• diabetic nephropathy, medication stable

Exclusion Criteria

• poor adherence of dietary recommendations, any changes in kind or dosage of medications

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
low GI	low GI	low GI: participants were asked to consume low GI foods (GI\<55) in abundant, medium GI in moderate and high GI (GI\>70) rarely.
low GL	low GI	low GL: participants were asked to consume low GI foods and the amount of carbohydrate was controlled.
conventional diet	conventional diet	conventional diet: all carbohydrate were treated as the same.

Primary Outcome Measures

Name	Time	Method
Serum creatinine (and blood urea nitrogen (BUN) (mg/dL) were measured by colorimetric method and enzymatic colorimetric method using commercial assay kit.	baseline, wk 12

Secondary Outcome Measures

Name	Time	Method
Serum levels of high sensitive C- reactive protein (hs-CRP) (mg/L) were quantified by using an ultrasensitive latex-enhanced immunoturbidimetric assay (Randox Laboratory Ltd., Belfast, United Kingdom).	baseline, wk 12

Trial Locations

Locations (1)

Leila Azadbakht; 🇮🇷 Isfahan, Iran, Islamic Republic of