A Randomized, Double-blind, Controlled Clinical Study of Human Umbilical Cord Mesenchymal Stem Cell(UC-MSC)Delayed Renal Chronic Kidney Disease(CKD3、4 )

The chronic kidney disease is caused by renal structural and functional impairment for more than 3 months due to various causes, including normal and abnormal glomerular filtration rate (GFR), abnormal blood, urine, and imaging findings, or an unexplained decline in GFR (<60 ml/min). Recent years, the incidence of chronic kidney disease has increased year by year worldwide, the incidence of CKD is 8% to 16% in the world's total population. The incidence of CKD and the primary causative factors vary from country to country and region, and the idemiological survey led by Peking University Hospital shows that the prevalence of CKD in China is 10.8% , the primary causative factor is glomerulonephritis, but as the incidence of hypertension and diabetes rises year by year, and the world will have more than 10 million people a year have acute kidney injury, the proportion of chronic kidney disease in the long-term course of the above population will be much higher than the normal population, chronic kidney disease has become an important public health problem in China and even the world.

Summarizing the basic and clinical studies at home and abroad, inflammatory factors such as inflammatory chemokines, cytokines, and reactive oxygen species interact with fibrosis factors such as mesangial cells, fibroblasts, and fibroblast activation, which are the root causes of the progression of CKD and the formation of tubular interstitial fibrosis and glomerular sclerosis and developing into end-stage renal disease.

Current treatments for chronic kidney disease are very limited, and to be precise, there is currently no cure for chronic kidney disease, nor is there a proven way to improve the kidneys survive after acute kidney injury (AKI). The progression of the disease itself can only be delayed as much as possible by changing the diet, controlling related complications with oral medications (such as hypertension, hyperlipidemia, nephropathy, etc.), and actively controlling blood glucose and glycosylated hemoglobin levels in patients with diabetes. For patients with stage CKD5 and more severe, renal replacement therapy is recommended, including hemodialysis and peritoneal dialysis, but there are many complications in both dialysis methods, such as narrowing of the internal fistula, occlusion, catheter infection, peritonitis, etc. The presence of the above complications will reduce the service life of the patient's dialysis pathway while also causing blows to other organ systems. Kidney transplantation may be considered when economic conditions permit and there is a matching kidney source, but kidney transplant surgery is riskier, and the average survival of transplanted kidneys is currently 12 years calculated by the American National Kidney Foundation, during this period, patients need to take anti-rejection drugs uninterruptedly, and these drugs (such as tacrolimus, cyclosporine, etc.) can also greatly damage the kidney organs and function. The above treatment methods have brought a heavy burden to patients and social medicine. In order to seek innovative and effective strategies to cultivate the limited regenerative capacity of the kidneys and reverse renal fibrosis, the mesenchymal stem cells (MSCs) with tissue regenerative potential and immunomodulatory functions have brought new ideas and hopes for the prevention and treatment of chronic kidney disease.

Progression in chronic kidney disease includes tubular interstitial fibrosis and glomerulosclerosis:

1. Tubular interstitial fibrosis is mainly characterized by tubular hypermetabolism, tubular epithelial-interstitial transition, and hypoxic damage to the renal interstitium, which eventually leads to infiltration of inflammatory cells, abnormal increase in extracellular matrix components in renal tissue, and disappearance of parenchymal cells. 2)Glomerulosclerosis is the outcome of excessive response of glomerular constituent related cells to injury, including structural changes, cells' gradual atrophy, shedding, apoptosis of cells, loss of anticoagulant properties, and increased expression of pro-inflammatory factors and pro-fibrosis factors; Proliferation of mesangial cells, mesangial differentiation into myofibroblasts, causing collagen III to be deposited in the renal units, leading to irreversible hardening of the glomeruli; The number of pinus process cells decreases, the skeleton retracts or flattens, and inflammatory cell aggregation of chemokines is released, while synthetic cytokines and growth factors further aggravate globules capillary sclerosis.