Prospective Stuy in Evaluating Hepatic Fibrosis Related to Hepatitis B Virus Using Non-invasive Parameters
- Conditions
- Hepatitis BLiver Fibrosis
- Registration Number
- NCT01962155
- Lead Sponsor
- Peking University First Hospital
- Brief Summary
The aim of our prospective study is to construct and validate a non-invasive model consisting biochemical markers, FibroScan, and radiological parameters for evaluating liver fibrosis caused by hepatitis B virus in mainland China.
- Detailed Description
Up to Oct, 2015,total of 1800 patients with chronic HBV infection were enrolled. Paired blood and liver biopsy samples were collected. Blood samples stored at -80 degree Celsius. Liver biopsy samples were judged by three pathology experts.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1841
- HBsAg positive for at least 6 months
- agree to have liver biopsy
- Male or female aged 18 to 65 years old
- Patients with alcoholic liver disease, autoimmune liver disease, heretic liver disease, drug induced liver disease,nonalcoholic liver disease or other chronic liver disease
- platelet count < 80000/L
- prothrombin activity β€ 60%
- patients with any disease or condition which the investigator or treating physician feels would interfere with the trial or the safety of the subject
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method determine whether a non-invasive test or a combination of non invasive tests may be used to accurately evaluate liver fibrosis in patients with chronic hepatitis B singular evaluation at the time of liver biopsy
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (30)
The Second Affiliated Hospital of Chongqing Medical University
π¨π³Chongqing, Chongqing, China
The People's Hospital of Guangxi Zhuang Autonomous Region
π¨π³Nanning, Guangxi, China
Henan Provincial People's Hospital
π¨π³Zhengzhou, Henan, China
The Second Xiangya Hospital of Central South Hospital
π¨π³Changsha, Hunan, China
Renmin Hospital of Wuhan University
π¨π³Wuhan, Hubei, China
The Third Affiliated Hospital of Xinxiang Medical University
π¨π³Xinxiang, Henan, China
The Third Affiliated Hospital of Sun Yat-sen University
π¨π³Guangzhou, Guangdong, China
The First Affiliated Hospital of Anhui Medical University
π¨π³Hefei, Anhui, China
Southwest Hospital, Third Military Medical University
π¨π³Chongqing, Chongqing, China
Shanghai Public Health Clinical Center
π¨π³Shanghai, China
Shanghai Ruijin Hospital
π¨π³Shanghai, China
Guangzhou Eighth People's Hospital
π¨π³Guangzhou, Guangdong, China
The First Affiliated Hospital with Nanjing Medical University
π¨π³Nanjing, Jiangsu, China
China-Japan Friendship Hospital
π¨π³Beijing, China
The Third people's Hospital of Shenzhen
π¨π³Shenzhen, Guangdong, China
The Third People's Hospital of Qinhuangdao
π¨π³Qinhuangdao, Hebei, China
Yantai City Hospital for Infectious Diseases
π¨π³Yantai, Shandong, China
Shan Xi Medical University
π¨π³Taiyuan, Shanxi, China
302 Military Hospital of China
π¨π³Beijing, Beijing, China
The Second Hospital of Nanjing
π¨π³Nanjing, Jiangsu, China
Beijing Ditan Hospital
π¨π³Beijing, Beijing, China
Zhejiang First Hospital
π¨π³Hang Zhou, Zhejiang, China
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
π¨π³Wuhan, Hubei, China
81 Military Hospital of China
π¨π³Nanjing, Jiangsu, China
Dalian the Sixth People's Hospital
π¨π³Dalian, Liaoning, China
West China Hospital, Sichuan University
π¨π³Chengdu, China
The Sixth People's Hospital of Shenyang
π¨π³Shenyang, Liaoning, China
Beijing Youan Hospital, Capital Medical University
π¨π³Beijing, China
The 305 Hospital of People's Liberation Army
π¨π³Beijing, China
Peking University First Hospital
π¨π³Bei Jing, Beijing, China