Patient-ventilator Asynchrony in Patients With Brain Injury

Completed

• Conditions: Brain Injuries; Mechanical Ventilation

• Registration Number: NCT03212482
• Lead Sponsor: Jian-Xin Zhou

Brief Summary

Mechanical ventilation is an important support strategy for critically ill patients. It could improve gas exchange, reduce the work of breathing, and improve patient comfort. However, patient-ventilator asynchrony, which defined as a mismatch between the patient and ventilator may obfuscate these goals. Studies have shown that a high incidence of asynchrony (asynchrony index \> 10%) is associated with prolonged mechanical ventilation and ICU length of stay and high mortality. So far, there have been only a few studies on the epidemiology of asynchrony in brain-injured patients. Investigators conduct a prospective observational study among brain-injured patients to determine the prevalence, risk factors and outcomes of patient-ventilator asynchrony. Esophageal pressure monitoring, a surrogate for pleural pressure, combined with airway pressure and flow waveforms is used to detect patient-ventilator asynchrony.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-06-15
• Study First Submitted: 2017-07-04
• Study First Submitted QC: 2017-07-07
• Study First Posted: 2017-07-11
• Primary Completion: 2019-07-01
• Study Completion: 2020-02-29
• Status Verified: 2020-05
• Last Update Submitted: 2020-05-28
• Last Update Posted: 2020-05-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• 1. ]older than 18 years 2) with brain injury in the ICU 3) mechanical ventilated for at least 72 hours

Exclusion Criteria

• 1. ICU length of stay less than 24 hours 2) enrolled in another trial

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The incidence of patient-ventilator asynchrony in brain-injured patients	Three days	The incidence of different types of patient-ventilator asynchrony in brain-injured patients.

Secondary Outcome Measures

Name	Time	Method
The risk factors of patient-ventilator asynchrony in brain-injured patients	Three days	The risk factors of different types of patient-ventilator asynchrony in brain-injured patients

Trial Locations

Locations (1)

Jian-Xin Zhou; 🇨🇳 Beijing, Beijing, China