Vitamin C in Children with Septic Shock- A Randomised Controlled Trial
Not Applicable
Completed
- Conditions
- Health Condition 1: I959- Hypotension, unspecified
- Registration Number
- CTRI/2020/01/022886
- Lead Sponsor
- All India Institute of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 218
Inclusion Criteria
1. Children 2 months to = 17 years of age admitted to the ICU with a diagnosis of septic shock
Exclusion Criteria
1. Children with chronic kidney disease.
2. Children with fulminant myocarditis
3. Children with dengue shock syndrome
4. Children on Vitamin C or Thiamine or steroid supplements
5. Children on anticancer drugs, drugs for autoimmune diseases
6. Children with G6PD deficiency
7. Children on iron supplements for iron deficiency anemia (can exaggerate iron absorption, iron overload and tissue damage)
8. Post-arrest shock and cardiac dysfunction
9. Moribund patients in who anticipated survival is < 24 hrs (adjuvant therapy may not make a difference as they are already in a downward spiral).
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Change in P-SOFA score at 72 hours from P-SOFA scores at the time of enrollment (referred to as ‘0’ hour score)Timepoint: 1. 72 hours of enrollment
- Secondary Outcome Measures
Name Time Method MortalityTimepoint: 28 day mortality