The effect of pre-versus postdilution and pore size on the clearance of mid size mocules.
Completed
- Conditions
- 10019280shock after cardiac arrest
- Registration Number
- NL-OMON33818
- Lead Sponsor
- Onze Lieve Vrouwe Gasthuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 36
Inclusion Criteria
Patients with shock after cardiac arrest, treated with hypothermia
Exclusion Criteria
no CVVH available
contra-indication nadroparin
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>As a marker for the clearance of smallmolecules, the concentration of<br /><br>creatinin, urea and ADMA will be measured. As a marker for the clearance of the<br /><br>midmolecules, the concentrations of β2-microglobuline en Interleukine-6 will be<br /><br>measured.<br /><br>The concentrations will be measured in the arterial blood, postfilter blood and<br /><br>in the ultrafiltrate. We will measure the hematocrit in the bloodsamples.<br /><br><br /><br>Primary endpoint<br /><br>Effectivity of the clearance of midmolecules, 15 minutes and 6 hours<br /><br>after start HVHF, expressed as:<br /><br>o Sieving coefficient<br /><br>o Concentration filtrate* filtrateflow</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secundary endpoints<br /><br>· Effectivity of the clearance of midmolecules, 12 hours after start HVHF<br /><br>· Hemodynamics<br /><br>· Metabolic control<br /><br>· Other organfailure</p><br>