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Clinical Trials/NCT05786456
NCT05786456
Active, Not Recruiting
N/A

Novel e-Health Intervention for Fear of Progression in Women With Gynecologic Cancer: A Pilot Study

City of Hope Medical Center1 site in 1 country23 target enrollmentJuly 19, 2024

Overview

Phase
N/A
Intervention
Discussion
Conditions
Malignant Female Reproductive System Neoplasm
Sponsor
City of Hope Medical Center
Enrollment
23
Locations
1
Primary Endpoint
Feasibility of recruitment (enrollment rate)
Status
Active, Not Recruiting
Last Updated
3 months ago

Overview

Brief Summary

This clinical trial studies how well an electronic (e)-health intervention (day-by-day) woks in managing fears or worries about cancer growing, spreading, or getting worse (progression) in patients with stage III or IV gynecologic cancer. Fear and worries about cancer progression or recurrence (coming back) are common concerns. This may contribute to concerns related to illness, worries, and uncertainty about the future. Day by Day is adapted from a program called "Conquer Fear" which was shown to benefit patients with early-stage cancer. Day-by-day intervention may help refocus patient thoughts and help patients learn skills to manage anxiety and fears.

Detailed Description

PRIMARY OBJECTIVES: I. Will adapt the intervention into a hybrid format including two group and three web based self-study sessions. (Phase 1) II. To determine the feasibility and acceptability of a new hybrid e-health intervention to manage fear of progression (FOP) in patients with stage III or IV gynecologic (GYN) cancer. (Phase 2) SECONDARY OBJECTIVE: I. To explore the preliminary efficacy of day-by-day (DBD) on reducing FOP (primary outcome) and improving secondary outcomes of distress, anxiety, depression, metacognitions, and mindfulness. (Exploratory) OUTLINE: PHASE I (DEVELOPMENT): Patients complete surveys and participate in focus groups. PHASE II (DBD): Patients receive DBD intervention consisting of group and web-based self-study sessions and check-in calls on study. Patients also watch videos and receive handouts to reinforce the group sessions.

Registry
clinicaltrials.gov
Start Date
July 19, 2024
End Date
December 15, 2026
Last Updated
3 months ago
Study Type
Interventional
Study Design
Single Group
Sex
Female

Investigators

Sponsor
City of Hope Medical Center
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Women with stage III or IV GYN cancer (ovarian, endometrial, cervical, vulvar/vaginal);at least 3 months from initial diagnosis
  • Age: \>= 18 years
  • Score \>= 34 on the Fear of Progression Short-Form, indicating dysfunctional levels
  • Ability to read and understand English
  • Patients in remission or with progressive disease are eligible

Exclusion Criteria

  • Enrolled in hospice
  • Severe depression as assessed by Patient Health Questionnaire (PHQ-9)
  • Non-English speaking
  • Prospective participants who, in the opinion of the investigator, may not be able to comply with all study procedures (including compliance issues related to feasibility/logistics)

Arms & Interventions

Supportive Care (DBD)

Patients receive DBD intervention consisting of group and web-based self-study sessions and check-in calls on study. Patients also watch videos and receive handouts to reinforce the group sessions.

Intervention: Discussion

Supportive Care (DBD)

Patients receive DBD intervention consisting of group and web-based self-study sessions and check-in calls on study. Patients also watch videos and receive handouts to reinforce the group sessions.

Intervention: Informational Intervention

Supportive Care (DBD)

Patients receive DBD intervention consisting of group and web-based self-study sessions and check-in calls on study. Patients also watch videos and receive handouts to reinforce the group sessions.

Intervention: Media Intervention

Supportive Care (DBD)

Patients receive DBD intervention consisting of group and web-based self-study sessions and check-in calls on study. Patients also watch videos and receive handouts to reinforce the group sessions.

Intervention: Questionnaire Administration

Supportive Care (DBD)

Patients receive DBD intervention consisting of group and web-based self-study sessions and check-in calls on study. Patients also watch videos and receive handouts to reinforce the group sessions.

Intervention: Telephone-Based Intervention

Outcomes

Primary Outcomes

Feasibility of recruitment (enrollment rate)

Time Frame: Up to 6 weeks

Defined by attendance, attrition, and skills practice adherence. Website acceptability is based on the System Usability Scale, log-in activity, activity completion rate, and most frequently visited site content.

Secondary Outcomes

  • Fear of progression (FOP)(Up to 12 weeks)

Study Sites (1)

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