Blood/Interstitial Glucose Measurements and Cognitive Function During Hypoglycemia and Recovery

Joslin Diabetes Center1 site in 1 country20 target enrollmentJanuary 2011

ConditionsHypoglycemia

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Hypoglycemia
Sponsor: Joslin Diabetes Center
Enrollment: 20
Locations: 1
Primary Endpoint: cognitive function correlation to blood or interstitial glucose
Status: Completed
Last Updated: 8 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to find out the effects of hypoglycemia on cognition in healthy individuals and how well changes in (interstitial) tissue glucose levels correlate with changes in cognitive function as compared to blood glucose levels.

Detailed Description

Subjects will undergo hypoglycemic clamps during which interstitial glucose will be measured and cognitive function will be assessed.

Registry

clinicaltrials.gov

Start Date

January 2011

End Date

October 2015

Last Updated

8 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Joslin Diabetes Center

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•non obese (BMI \<30), ages 18-50

Exclusion Criteria

•renal or hepatic failure
•cancer or lymphoma
•malabsorption or malnourishment
•hypercortisolism
•alcoholism or drug abuse
•eating disorder or depression
•coronary artery disease
•Arrhythmias
•hypertension
•on medications known to affect the blood glucose to be measured such as

Outcomes

Primary Outcomes

cognitive function correlation to blood or interstitial glucose

Time Frame: 1 year

This investigator initiated study will evaluate cognitive function at the onset, during and following recovery from hypoglycemia and will determine if cognitive function correlates better with blood or interstitial glucose concentrations.