Blood/Interstitial Glucose Measurements and Cognitive Function During Hypoglycemia and Recovery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- cognitive function correlation to blood or interstitial glucose
研究概览
简要总结
The purpose of this study is to find out the effects of hypoglycemia on cognition in healthy individuals and how well changes in (interstitial) tissue glucose levels correlate with changes in cognitive function as compared to blood glucose levels.
详细描述
Subjects will undergo hypoglycemic clamps during which interstitial glucose will be measured and cognitive function will be assessed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •non obese (BMI <30), ages 18-50
排除标准
- •renal or hepatic failure
- •cancer or lymphoma
- •malabsorption or malnourishment
- •hypercortisolism
- •alcoholism or drug abuse
- •eating disorder or depression
- •coronary artery disease
- •Arrhythmias
- •hypertension
- •on medications known to affect the blood glucose to be measured such as
- •glucocorticoids
- •on blood thinning agents
- •Pregnant women, breastfeeding women and women who want to become pregnant in the next 6 months will be excluded from the study.
- •Subjects who have donated blood two weeks prior to the study.
- •Allergies to pig derived products (Heparin will be used)
研究组 & 干预措施
Euglycemic and hypoglycemic clamp
Subjects will complete clamp study visit.
干预措施: euglycemic and hypoglycemic clamp (Procedure)
结局指标
主要结局
cognitive function correlation to blood or interstitial glucose
时间窗: 1 year
This investigator initiated study will evaluate cognitive function at the onset, during and following recovery from hypoglycemia and will determine if cognitive function correlates better with blood or interstitial glucose concentrations.
次要结局
未报告次要终点