Competing Risk of Death and ESRD in Incident CKD Patients

Completed

• Conditions: Chronic Kidney Diseases

• Registration Number: NCT03379571
• Lead Sponsor: Central Hospital, Nancy, France

Brief Summary

Although chronic kidney disease (CKD) affects a growing number of people, epidemiologic data on incident CKD in the general population are scarce. Screening strategies to increase early CKD detection have been developed.

Methods: From a community-based sample of 4,409 individuals residing in a well-defined geographical area, investigators determined the number of patients having a first serum creatinine value ≥1.7 mg/dL and present for at least 3 months that allowed us to calculate an annual incidence rate of CKD (stages 3 to 5). CKD (stages 3 to 5) was defined by estimated glomerular filtration rate (eGFR) \<60 mL/min/1.73 m2. Investigators also described the primary care, outcomes and risk factors associated with outcomes using competing risks analyses for these CKD patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2004-01-01
• Primary Completion: 2009-12-31
• Study Completion: 2009-12-31
• Status Verified: 2017-12
• Study First Submitted: 2017-12-04
• Study First Submitted QC: 2017-12-15
• Last Update Submitted: 2017-12-15
• Study First Posted: 2017-12-20
• Last Update Posted: 2017-12-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 631

Inclusion Criteria

• >= 18 years
• first serum creatinine value ≥1.7 mg/dL reached after January 1st, 2004
• and present for at least 3 months
• residing in the given geographical area (the Urban Community of Greater Nancy (UCGN))

Exclusion Criteria

• <18 years
• prevalent CKD patient : CKD diagnosis before January 1st, 2004
• patients on dialysis or renal transplanted
• refusal of participation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
annual incidence rate of CKD	inclusion	number of patients residing in a well-defined geographical area having a first serum creatinine value ≥1.7 mg/dL after January 1st, 2004 and still present for at least 3 months

Secondary Outcome Measures

Name	Time	Method
dialysis initiation	through study completion, 6 year after study start	number of dialysis initiation.
death	through study completion, 6 year after study start	number of death
management of CKD patients	through study completion, 6 year after study start	%patients referred to a nephrologist, decline of the renal function