Multiple Doses of Gabapentin and Postoperative Morphine Consumption in Total Knee Arthroplasty
Overview
- Phase
- Not Applicable
- Intervention
- Gabapentin
- Conditions
- Post Operative Pain
- Sponsor
- McMaster University
- Enrollment
- 101
- Locations
- 1
- Primary Endpoint
- Amount of morphine consumption
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
Total knee arthroplasty is amongst the most painful procedures postoperatively, and pain management can be a challenge. Different measures have been introduced to manage severe postoperative pain int hese patients. Previous studies have investigated gabapentin in acute postoperative pain and demonstrated reducted pain, postoperative morphine consumption, morphine related side effects, and postoperative pain scores. To date, this analgesia adjunct has yet to be investigated in total joint arthroplasty patients.
Detailed Description
The study was submitted to Health Canada and received the letter of no objection. A randomized, double-blind, placebo-controlled study. The randomization scheme will be prepared and will be done by the pharmacy department at McMaster University. Ninety patients undergoing primary knee arthroplasty will be recruited from the preoperative clinic. Forty-five patients in each population will be allocated to a gabapentin group and the other forty-five to a placebo group.
Investigators
Eligibility Criteria
Inclusion Criteria
- •participants aged 19-90
- •elective single joint, primary total knee arthroplasty
- •use of PCA with morphine for postoperative pain control has been discussed and agreed upon between patient and anesthetist
Exclusion Criteria
- •bilateral total knee arthroplasty
- •revision knee arthroplasty
- •underlying disease of epilepsy, seizure, or chronic pain syndrome
- •active gastrointestinal bleeding within the last 6 months
- •history of non-steroidal anti-inflammatory drug (NSAID) induced asthma
- •known or suspected history of drug or alcohol abuse
- •participant currently takes gabapentin or pregabalin for any reason
- •participant currently takes pain medication that is more potency than codeine or oxycodone (morphine, hydromorphone, meperidine, methadone, fentanyl, including any long acting narcotics)
- •known allergy to study medications: gabapentin, morphine, NSAID, acetaminophen
- •unable to tolerate morphine
Arms & Interventions
Gabapentin
Gabapentin 600 mg will be given per oral two hours preoperatively and 200 mg three times daily after surgery (600 mg/day).
Intervention: Gabapentin
Placebo
Placebo will match the the gabapentin pill and will be given orally.
Intervention: Placebo
Outcomes
Primary Outcomes
Amount of morphine consumption
Time Frame: 2 years
Secondary Outcomes
- Side effects(2 years)