Study to assess efficacy of Doxycycline in Improving Filarial Lymphedema in India
- Conditions
- Health Condition 1: B741- Filariasis due to Brugia malayi
- Registration Number
- CTRI/2017/08/009312
- Lead Sponsor
- Task Force for Global Health
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 235
Resident in endemic area for filariasis for >5yrs
-Body weight >40Kg
-Lymphedema of a limb stage 1-6 measured on a 7 point scale
-Able to give informed consent
-Ability to use established methods of hygiene
-Normal laboratory profile
-No lymphedema or lymphedema stage 7
-Age < 14 years or > 65 years
-Body weight < 40 kg
-Pregnant or breastfeeding women
-Women of childbearing potential not using an agreed method of contraception. (A pregnancy test will be conducted as part of the screening process to exclude pregnancy and repeated at 3 and 8 weeks. In addition, women of childbearing potential will be counseled against pregnancy during the treatment period)
-Clinical or laboratory evidence of hepatic or renal dysfunction or CNS disease
-Alcohol or drug abuse
-History of adverse reactions to doxycycline or other tetracyclines
-Patient has any situation or condition that may interfere with participation in the study as judged by the clinical investigator
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method