Validation of the thrombin generation assay in pregnancy
- Conditions
- Women in the last trimester of their pregnancy.
- Registration Number
- NL-OMON24748
- Lead Sponsor
- niversity Medical Center
- Brief Summary
. M. de Lange*, L. E. van Rheenen-Flach, M. D. Lance´ , L. Mooyman4, M.Woiski, E. C. van Pampus,M. Porath, A. C. Bolte2, L. Smits, Y. M. Henskens and H. C. Scheepers. BJA-2014: Peri-partum reference ranges for ROTEM thromboelastometry
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
All healthy, adult women who are in the final trimester of their pregnancy.
Exclusion Criteria
Acquired and inherited coagulation abnormalities.
HELLP-syndrome and pre-eclampsia.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary outcome is a reference range for a plasma thrombin generation assay and a newly developed whole blood thrombin generation assay.
- Secondary Outcome Measures
Name Time Method Correlation with peri-partal bleeding.
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie thrombin generation assay validation in late pregnancy?
How does thrombin generation assay compare to standard coagulation tests in pregnant women?
Which biomarkers correlate with ROTEM thromboelastometry reference ranges in the last trimester?
What adverse events are associated with thrombin generation assay use in obstetric care?
Are there alternative anticoagulant monitoring strategies for pregnant patients undergoing surgery?