Probiotics, immune health and sleep disruptio

Not Applicable

Completed

• Conditions: immune health; sleep disruption / deprivation; Inflammatory and Immune System - Normal development and function of the immune system

• Registration Number: ACTRN12617001552370
• Lead Sponsor: Griffith University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-11-13
• Last Update Posted: 16 September 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

engaged in a rotating work roster involving night shift work

Exclusion Criteria

•Has consumed probiotics, antibiotics or prebiotics in the previous 8 weeks
•Has undergone treatment with systemic corticosteroids in the previous 6 months
•uses immune-modulating medications or medications that alter sleep onset/quality
•Is pregnant or possibly pregnant
•Has current illness with a bacterial or viral infection

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Immunoscore - designed for use in this study based on circulating concentrations of C-reactive protein, fibrinogen, pentraxin, E-selectin, VCAM and inflammatory cytokines (IL-6, TNF-a, IL-1B, IL-10 and IL-1RA).[day 15]

Secondary Outcome Measures

Name	Time	Method
intestinal permeability score - designed for use in this study based on a combination of circulating concentrations of lipopolysaccharide, lipopolysaccharide binding protein and intestinal fatty acid binding protein[day 15]