Ayurvedic Management of Chronic Kidney Disease

Not Applicable

Completed

• Conditions: Hypertensive Nephropathy; Diabetic Nephropathy
• Interventions: Other: Ayurveda treatment

• Registration Number: NCT02477163
• Lead Sponsor: J.S. Ayurveda College

Brief Summary

The purpose of this study is to determine the effect of multi-dimentional ayurvedic treatment in the patients of various types of chronic kidney disease.

Detailed Description

Ayurvedic treatment includes some complex classical herbal formulations and Niruha basti (procto-colonic administration of ayurvedic medicines mainly contained decoction of punarnavadi compound, rocksalt, sesame oil and mixture of some herbal poweders) will be given to the patients of chronic kedney disease who are not on dialysis. Patients of CKD of various etiology will be grouped accordingly and will get the same treatment.

Study Timeline

• Study Start: 2014-01
• Study First Submitted: 2015-06-11
• Study First Submitted QC: 2015-06-19
• Study First Posted: 2015-06-22
• Primary Completion: 2021-06-30
• Status Verified: 2021-07
• Study Completion: 2022-04-30
• Last Update Submitted: 2022-08-10
• Last Update Posted: 2022-08-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 521

Inclusion Criteria

• Patients having a confirm diagnosis of chronic kidney disease with GFR level < 60mL/min and persistent (present for > 3 months) indicates substantial reduction in kidney function. Confirmation of diagnosis with ultrasound of KUB, indicating reduction of kidney size and / or cortico-medullary difference.

Exclusion Criteria

• Female patients having pregnancy, breast feeding or post-delivery period.
• Patients who are on dialysis treatment from more than 6 months period. Patients who are already operated for renal transplantation and then having nephropathy.
• Patients with some serious illness like cardio-vascular diseases, acute mental disorders, serious acute organic diseases, serious chronic co-morbidity, hypo or hyper thyroidism, other kidney, liver or metabolic disorders etc.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
single group	Ayurveda treatment	Patients of chronic renal failure

Primary Outcome Measures

Name	Time	Method
Changes in the value of laboratory investigations	4 weeks	All the related laboratory investigations will be done before and after the treatment. Effect will be assessed with the help of reduction level in serum creatinine(in mg /dl), blood urea(in mg/dl), serum uric acid(in mg/dl) and improvement in hemoglobin(in gm%) and serum electrolytes level(in mmol/l).
Improvement in the signs and symptoms	4 weeks	Following grade score will be used to measure the improvement in all the patients at the initial level and after the treatment.; Grade score of signs and symptoms; 1. Oedema: No oedema(0); Slight oedema on lower extremties(1); Severe oedema on lower extrimities(2); Anasarca(3); 2. General weakness: No weakness(0); Mild weakness(1); Moderate weakness(2); Severe weakness(3); 3. Loss of appetite: Good appetite(0) Mild loss of appetite(1); Moderate loss of appetite(2); Complete loss of appetite(3); 4. Nausea / Vomiting: Absent(0); Occasional(1); Once or twice a week(2); Daily(3); 5. Muscle cramps: Absent(0); Occasional(1); Once or twice a week(2); Daily(3); 6. Breathlessness: Absent(0); On fast walking or climbing stairs(1); Sometimes at rest(2); Generally occurs at rest(3); 7. Hiccup: Absent(0); Occasional(1); Once or twice a week(2); Daily(3); 8. Pruritus: Absent(0); Mild(1); Moderate(2); Severe(3)

Trial Locations

Locations (1)

P D Patel Ayurveda Hospital; 🇮🇳 Nadiad, Gujarat, India