Mechanism research for external therapy of warming channels activating blood circulation early treating knee osteoarthritis based on metabonomics technique

Jiangsu Provinve Hospital of TCM0 个研究点开始时间: 待定最近更新: 2023年2月20日

适应症

试验速览

暂无简介。

•1 Meet the western medical diagnostic criteria for knee osteoarthritis: adopt the 2015 American orthopaedic surgeons association knee joint bone
•Evidence-based guidelines for arthritis:
•(1) Repeated pain in the knee joint within a month.
•(2) X-ray (standing position or weight-bearing position) showed narrowing of joint space, subchondral osteosclerosis and/or cystic degeneration, formation of marginal osteophytes.
•(3) Articular fluid (at least twice) is clear and thick, WBC < 2000/ml.
•(4) Middle-aged and elderly patients (40 years old).
•(5) Morning stiffness 30 minutes.
•(6) Bone friction when moving.
•Note: combined with clinical, laboratory and X-ray examination, 1+2 or 1+3+5+6 or 1+4+5+6 were diagnosed as osteoarthritis of knee joint.
•2 Above 40 years old;
•3 If the patient has received other non-surgical treatment, after 7 days of washout period;
•4 Signed the informed consent.

•(1) knee osteoarthritis with acute synovitis;
•(2) knee joint tuberculosis, tumor, rheumatoid arthritis, rheumatoid arthritis;
•(3) and affect the joint, such as psoriasis, plum toxic neuropathy, brown and yellow disease, metabolic bone disease,Acute trauma, etc.
•(4) received systemic or intra-articular hormone therapy within nearly 60 days, and the knee joint within 3 months
•Intracavitary injection or arthroscopy;
•(5) injured skin damage, or other diseases affect the local injury medicine, such as skin diseases;
•(6) allergy patients;
•(7) women who are lactating, during pregnancy or are preparing for pregnancy;
•(8) patients who are participating in clinical trials of other drugs;
•(9) in addition to osteoarthritis of the knee, pain relievers (eg acetyl Aminophenol, nonsteroidal anti-inflammatory drugs, nonprescription compounds containing analgesics, and possibly analgesics Sexual ingredients of traditional Chinese medicine, local painkillers) were used for other chronic or recurrent pain;
•(10) attending according to the researcher's judgment, attending may reduce the possibility of admission or other attending complications A condition, such as frequent changes in the working environment, that may cause loss of access.

发起方

Jiangsu Provinve Hospital of TCM