Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo

Phase 3

Completed

• Conditions: HC-BPPV
• Interventions: Procedure: Gufoni maneuver; Procedure: Head-shaking maneuver; Procedure: sham maneuver

• Registration Number: NCT00810641
• Lead Sponsor: Chonbuk National University

Brief Summary

The purpose of this study was to compare the immediate efficacies of each treatment maneuvers in treatment of apogeotropic horizontal canal benign paroxysmal positional vertigo (HC-BPPV).

Detailed Description

A randomized prospective study of patients with HC-BPPV. Patients with apogeotropic type of HC-BPPV were randomized to one of each three treatment groups at their first clinic visit. These groups included the Gufoni maneuver, head-shaking maneuver, and sham group in apogeotropic HC-BPPV. Responsiveness of treatment maneuver was determined by positioning maneuver immediately after each treatment method based on resolves of vertigo and positional nystagmus.

Study Timeline

• Study First Submitted: 2008-12-17
• Study First Submitted QC: 2008-12-17
• Study First Posted: 2008-12-18
• Study Start: 2009-01
• Status Verified: 2011-05
• Primary Completion: 2011-05
• Study Completion: 2011-05
• Results First Submitted: 2011-05-25
• Results First Submitted QC: 2011-05-31
• Last Update Submitted: 2011-05-31
• Results First Posted: 2011-06-27
• Last Update Posted: 2011-06-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 157

Inclusion Criteria

• a history of brief episodes of positional vertigo,
• direction-changing horizontal nystagmus beating toward the uppermost (apogeotropic nystagmus) or undermost (geotropic nystagmus) ear in both the lateral head turning positions,
• no spontaneous nystagmus during upright sitting position, and
• absence of identifiable central nervous system disorders that could explain the positional vertigo and nystagmus.

Exclusion Criteria

• central positional nystagmus with identifiable CNS lesions that could explain the positional nystagmus

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Gufoni maneuver	Gufoni maneuver	Gufoni maneuver for apogeotropic HC-BPPV
Headshaking maneuver	Head-shaking maneuver	headshaking maneuver for apogeotropic HC BPPV
sham maneuver	sham maneuver	sham maneuver for apogeotropic HC BPPV

Primary Outcome Measures

Name	Time	Method
Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo: A Randomized Clinical Trial	one hour	The immediate treatment response was determined by participating neurologists in each clinic without knowing the maneuver applied to each patient from 30 minutes to one hour after initial maneuver. The absence of both vertigo and nystagmus was required to determine a resolution.

Trial Locations

Locations (2)

Chonbuk National University Hospital; 🇰🇷 Jeonju, Cholabuk-do, Korea, Republic of

Seoul National University Bundang Hospital; 🇰🇷 Seongnam, Kyoungki-do, Korea, Republic of