Different Resistance Training Intensity Prescription and Monitoring Methodologies: Effects on Strength, Body Composition, and Well-being in Survivors of Breast Cancer
- Conditions
- Breast Cancer
- Registration Number
- NCT06940310
- Lead Sponsor
- Universidad de Almeria
- Brief Summary
The goal of this clinical trial is to compare the effects of three different methods of prescribing and monitoring resistance training intensity on muscle strength, body composition, quality of life, fatigue, anxiety, and depression in breast cancer survivors.
- Detailed Description
Breast cancer survival rates have significantly increased in recent years, highlighting the importance of effective interventions to address the long-term consequences of cancer and its treatments. Breast cancer survivors often experience muscle weakness, changes in body composition, fatigue, and psychological distress, which can negatively impact their quality of life. Resistance training has been widely recognized as a safe and effective strategy to counteract these effects, improving muscle strength, body composition, and psychological well-being.
Despite its benefits, the optimal method for prescribing and monitoring resistance training intensity in breast cancer survivors remains unclear. Traditional methods based on one-repetition maximum (1RM) testing may not fully account for individual variations in fatigue and performance. Alternative approaches, such as load-velocity relationships, allow for more precise and real-time adjustments to training intensity, potentially optimizing outcomes.
This randomized controlled trial aims to compare the effects of three different methods of resistance training intensity prescription and monitoring on muscle strength, body composition, quality of life, fatigue, anxiety, and depression in breast cancer survivors. The findings will contribute to developing evidence-based exercise guidelines, enhancing rehabilitation strategies and overall well-being in this population.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Female
- Target Recruitment
- 60
- To be >18 years old.
- To have a breast cancer diagnosis.
- To have finished chemotherapy, radiotherapy and/or surgery up to 10 years prior to the beginning of the study.
- To present metastatic breast cancer.
- To have a planned surgery for breast reconstruction within three months after the start of the study.
- To present any absolute contraindication for exercising.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Muscular strength Change from baseline to week 8 The main variable of the present study will be muscle strength, assessed by determining peak isometric strength in the bench press and squat exercises using force platforms.
- Secondary Outcome Measures
Name Time Method Body weight (InBody 770) Change from baseline to week 8 Body wieght (kg) will be determined using bioelectrical impedance analysis (InBody 770; InBody Co Ltd, Seoul, Korea).
Total fat mass (InBody 770) Change from baseline to week 8 Total fat mass (kg) will be determined using bioelectrical impedance analysis (InBody 770; InBody Co Ltd, Seoul, Korea).
Fat percentage (InBody 770) Change from baseline to week 8 body fat percentage (%) will be determined using bioelectrical impedance analysis (InBody 770; InBody Co Ltd, Seoul, Korea).
Fat-free mass (InBody) Change from baseline to week 8 Fat-free mass (kg) will be determined using bioelectrical impedance analysis (InBody 770; InBody Co Ltd, Seoul, Korea).
Handgrip strength Change from baseline to week 8 Handgrip strength will be determined using a digital dynamometer (Model T.K.K.540; Takei Scientific Instruments Co, Ltd).
Visceral fat mass level (InBody) Change from baseline to week 8 Visceral fat mass level (U) will be determined using bioelectrical impedance analysis (InBody 770; InBody Co Ltd, Seoul, Korea).
Muscle function (5STS) Change from baseline to week 8 Muscle function will be assessed using the 30-second sit-to-stand test. Additionally, the five-repetition sit-to-stand (5STS) test will be performed on force platforms, and the peak force of all repetitions will be recorded.
Height (scale) Baseline Height will be determined using a scale (cm)
Health-related quality of life (FACT-B) Change from baseline to week 8 Quality of life will be assessed using the Functional Assessment of Cancer Therapy-Breast (FACT-B) questionnaire. The global score ranges from 0 to 148 where higher scores indicate better quality of life.
Cancer-related fatigue (FACIT-F) Change from baseline to week 8 Fatigue will be assessed using the Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F) questionnaire. The score ranges from 0 to 52, where higher scores indicate lower levels of fatigue.
Anxiety and depression (HADS) Change from baseline to week 8 Anxiety and depression will be determined using the Hospital Anxiety and Depression Scale (HADS). Scores range from 0 to 21 for both HADS-A (Anxiety) and HADS-D (Depression) subscales, where higher scores indicate more severe symptoms of anxiety or depression.
Patient global impression of change Week 8 Patient global impression of change after the intervention will be evaluated at the end of the trial using a single Likert-type question.
Trial Locations
- Locations (1)
University of Almeria
🇪🇸Almeria, Spain